ULTRASTRUCTURAL STUDIES ON MUSCULAR ATROPHY IN MAREK'S DISEASE : I. DENERVATION ATROPHY IN CHICKEN SKELETAL MUSCLE A LIGHT AND ELECTRON MICROSCOPIC STUDY

概要

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When denervation was performed by nerve-cutting and nerve-crushing in chickens, three phases could be observed morphologically. The first phase was characterized by foregoing degenerative changes of the neuro-muscular junctions (axon terminals), followed by atrophic changes of the muscle fibers. The second phase was characterized by irregular arrangement of the myofilaments in atrophic muscle fibers and appearance of regenerative muscular changes by 20 days after denervation. By this time, no morphological differences could be discerned between the nerve-cut and the nerve-crushed specimens. The third phase was characterized by distinct morphological differences between the nerve-cut and the nerve-crushed specimens. This phase began from the 30-day after denervation. These differences became more marked day by day. On the 60- day after denervation, almost all muscle fibers showed normal structures of the myofibrils in the nerve-crushed specimens, whereas, muscle fibers were still atrophic in the nerve-cut specimens.
北海道大学の論文
1986-01-31