TWO-YEAR FEED STUDY OF CARCINOGENICITY AND CHRONIC TOXICITY OF ORTHO-CHLORONITROBENZENE IN RATS AND MICE
スポンサーリンク
概要
- 論文の詳細を見る
Carcinogenicity and chronic toxicity of ortho-chloronitrobenzene (o-CNB) were examined by feeding groups of 50 F344 rats and 50 BDF_1 mice of both sexes o-CNB-containing diets for 2 years. The dietary concentration of o-CNB was 0, 80, 400 or 2000 ppm (w/w) for rats and 0, 100, 500 or 2500 ppm for mice. The 2-year administration of o-CNB produced a dose-dependent increase in incidences of hepatocellular adenomas and carcinomas in rats and mice of both sexes and hepatoblastomas in mice of both sexes. Incidences of altered cell foci in the liver were increased in the o-CNB-fed rats of both sexes. Metastasis from mouse malignant liver tumors occurred predominantly in the lung. The hepatocarcinogenic response to o-CNB was found to be more potent in mice than in rats. Marginally increased incidences of renal cell adenomas in the 2000 ppm-fed female rats and renal cell carcinomas in the 2000 ppm-fed male rats were noted, together with a significantly increased incidence of atypical tubule hyperplasias. Spontaneous, age-related chronic progressive nephropathy was exacerbated in a dose-related manner, and caused the death of 47 male rats fed 2000 ppm before the end of the 2-year administration period. The highest dose levels of o-CNB except for the administration of 2000 ppm to male rats were thought to meet the criteria of the maximum tolerated dose set by both NCI and IARC guidelines. Causative factors of o-CNB-induced carcinogenicity were discussed with reference to our previous rodent studies of subchronic toxicity of o-CNB and carcinogenicity and chronic toxicity of para-chloronitrobenzene.
- 2006-08-23
著者
-
MATSUSHIMA Taijiro
Japan Bioassay Research Center
-
Yamazaki Kazunori
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
-
Aiso Shigetoshi
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
-
Nagano Kasuke
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
-
Senoh Hideki
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Nagano Kasuke
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
長野 嘉介
Division Of Pathology Japan Bioassay Research Center
-
Nagano Kasuke
Japan Bioassay Research Center
-
Yamamoto Seigo
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Suzuki Masaaki
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
相磯 成敏
中災防 日本バイオアッセイ研究センター
-
KANO Hirokazu
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
-
UMEDA Yumi
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
-
MATSUMOTO Michiharu
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
-
ARITO Heihachiro
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
-
Kasai Tatsuya
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
-
Yamazaki K
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Arito Heihachiro
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
-
Katagiri Taku
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Kano Hirokazu
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Aiso Shigetoshi
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Aiso Shigetoshi
Division Of Pathology Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Umeda Yumi
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Nagano K
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Senoh Hideki
Department Of Pathology Japan Bioassay Research Center
-
Yamazaki Kazunori
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Senoh Hideki
中央労働災害防止協会日本バイオアッセイ研究センター
-
松本 道治
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
ARITO Heihaciro
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
-
相磯 成敏
Division Of Pathology Japan Bioassay Research Center
-
Matsushima Taijiro
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Matsushima Taijiro
Japan Industrial Safety And Health Assoc. Kanagawa Jpn
-
Matsushima Taijiro
Japan Bioassay Laboratory
-
Kasai Tatsuya
中央労働災害防止協会日本バイオアッセイ研究センター
-
長野 嘉介
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Yamazaki Kazunori
Occupational Health Res. And Dev. Center Japan Industrial Safety And Health Assoc.
-
Aiso Shigetoshi
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
-
Nagano Kasuke
中央労働災害防止協会日本バイオアッセイ研究センター
-
Yamazaki Kazunori
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
関連論文
- グリオキサルのF344ラット及びBDF_1マウスへの長期経口投与による毒性
- アントラセンのF344ラット及びBDF_1マウスへの長期経口投与による毒性
- パラジクロロベンゼンの2年間吸入暴露によるマウスとラットのがん原性と慢性毒性(毒性学)
- Eradication of Helicobacter pylori induces apoptosis and inhibits proliferation of heterotopic proliferative glands in infected Mongolian gerbils
- β-Catenin gene alteration in glandular stomach adenocarcinomas in N-methyl-N-nitrosourea-treated and Helicobacter pylori-infected Mongolian gerbils
- β-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas
- Effect of early eradication on Helicobacter pyloirirelated gastric carcinogenesis in Mongolian gerbils
- Earlier Helicobacter pylori Infection Increases the Risk for the N-Methyl-N-nitrosourea-induced Stomach Carcinogenesis in Mongolian Gerbils
- Synergistic Promoting Effects of Helicobacter pylori Infection and High-salt Diet on Gastric Carcinogenesis in Mongolian Gerbils
- Reversibility of Heterotopic Proliferative Glands in Glandular Stomach of Helicobacter pylori-infected Mongolian Gerbils on Eradication
- アミン系エポキシ樹脂硬化剤の亜急性毒性について
- 189. アミン系エポキシ樹脂硬化剤の亜急性毒性について (その他有害物質)
- P164 有機溶剤の有害性データベースの構築 : 当センターで実施した試験結果を中心に
- Absence of β-catenin Mutations in Mouse Hepatoblastomas Induced by N,N-dimethylformamide
- Enhanced proliferative response of hepatocytes to combined inhalation and oral exposures to N,N-dimethylformamide in male rats
- P1009 臭素化ダイオキシンによるラットの単回経口投与毒性 : 全身症状と造血系への影響(一般演題:ポスター,地方の時代の産業保健,第79回日本産業衛生学会)
- P1008 臭素化ダイオキシンによるラットの単回経口投与毒性 : 肝臓への影響(一般演題:ポスター,地方の時代の産業保健,第79回日本産業衛生学会)
- P1007 臭素化ダイオキシンによるラットの発生毒性 : 胎児および乳児への影響(一般演題:ポスター,地方の時代の産業保健,第79回日本産業衛生学会)
- ビフェニルの 2 年間混餌投与によるマウスのがん原性(毒性学)
- P2070 アリルクロリドのラット及びマウスへの吸入曝露によるがん原性と慢性毒性
- P2069 アクリル酸=2-ヒドロキシエチルのラット及びマウスへの経口投与によるがん原性と慢性毒性
- P2068 ο-フェニレンジアミン二塩酸塩のラット及びマウスへの経口投与によるがん原性と慢性毒性
- P2067 1, 4-ジクロロ-2-ニトロベンゼンのラットとマウスへの経口投与によるがん原性と慢性毒性
- ラット及びマウスの腫瘍性・非腫瘍性病変を用いたクロロホルムのリスクアセスメント
- P442 ジクロロメタンのF344ラット及びBDF_1マウスへの長期吸入暴露による毒性
- P429 ヒドラジン : 水加物のF344ラット及びBDF_1マウスへの長期経口投与による毒性
- Difference in Target Organs in Carcinogenesis with a Heterocyclic Amine, 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline, in Different Strains of Mice
- Incidence of Respiratory Metaplasia of the Nasal Gland Epithelium in Untreated F344 Rats and BDF1 Mice Subjected to Two-Year Carcinogenicity Studies
- Increased Incidence of Foreign Body Rhinitis in F344 Rats during Two-year Inhalation Exposure to Methyl Bromide
- Occurrence of Foreign Body Rhinitis in F344 Rats During Toxicologic Studies
- P1015 1-ブロモ-3-クロロプロパンのラット及びマウスへの吸入曝露によるがん原性と慢性毒性(一般演題:ポスター,地方の時代の産業保健,第79回日本産業衛生学会)
- P1014 2,4-ジクロロ-1-ニトロベンゼンのラット及びマウスへの経口投与によるがん原性と慢性毒性(一般演題:ポスター,地方の時代の産業保健,第79回日本産業衛生学会)
- P1012 アセト酢酸メチルのラット及びマウスへの経口投与によるがん原性と慢性毒性(一般演題:ポスター,地方の時代の産業保健,第79回日本産業衛生学会)
- Enhanced hepatocarcinogenicity by combined inhalation and oral exposures to N,N-dimethylformamide in male rats
- Carcinogenicity and Chronic Toxicity in Rats and Mice Exposed by Inhalation to 1,2-Dichloroethane for Two Years
- Oral Carcinogenicity and Toxicity of 2-Amino-4-chlorophenol in Rats
- Design and performance of a system for blood collection of rats under whole-body inhalation exposure
- Identification of an N-acetylcysteine conjugate in the urine after oral administration of 2,4-dichloro-1-nitrobenzene to rats
- Thirteen-week oral toxicity of 1,4-dioxane in rats and mice
- Thirteen-week Inhalation Toxicity of Carbon Tetrachloride in Rats and Mice
- Changes in the Testicular Damage Caused by Indium Arsenide and Indium Phosphide in Hamsters during Two Years after Intratracheal Instillations
- Genetic Alteration in Carcinoid Tumors of the Lung
- TIME-DEPENDENT INDUCTION OF MICRONUCLEATED HEPATOCYTES BY DIETHYLNITROSAMINE, 2-ACETYLAMINOFLUORENE AND MITOMYCIN C
- Effects of Inhalation Exposure to Propylene Oxide on Respiratory Tract, Reproduction and Development in Rats
- Developmental Toxicity Induced by Inhalation Exposure of Pregnant Rats to N,N-Dimethylacetamide
- Systemic and Myelotoxic Effects of Single Administration of 2, 3, 7, 8-Tetrabromodibenzo-p-Dioxin in Rats
- Adenoma of the Nasal Submucosal Glands in the BDF_1 Mouse : One Case among 2000 Controls in 2-year Carcinogenicity Studies
- O10-13 Reproductive and Developmental Toxicity of 1-bromopropane in Rats.
- P-35 Multiple-route Exposure Effects of Chloroform on Rat Liver Microsomes and Cytosols Activity(Proceedings of the 27th Annual Meeting)
- DEVELOPMENT OF RESISTANCE TO CHLOROFORM TOXICITY IN MALE BDF_1 MICE EXPOSED TO A STEPWISE INCREASE IN CHLOROFORM CONCENTRATION
- Inhalation Toxicology Studies of Chloroform in BDF_1 mice
- Micronuclei Induction of Methyl Bromide in Rats and Mice by Sub-chronic Inhalation Toxicity Test
- 211 ON AVAILABILITY OF HISTOGRAM AND RADARGRAN IN HEMATOLOGICAL AND BLOOD BIOCHEMICAL ANALYSIS FOR LONG TERN TOXICITY STUDIES
- Mutagenicity Study of Carbon Tetrachloride and Chloroform with Microbial Mutagenicity Test and Rat Liver Micronucleus Test
- A Pathological Study on Spontaneous Hepatic Neoplasms in BDF1 Mice
- TWO-YEAR FEED STUDY OF CARCINOGENICITY AND CHRONIC TOXICITY OF ORTHO-CHLORONITROBENZENE IN RATS AND MICE
- THIRTEEN-WEEK ORAL TOXICITY OF PARA- AND ORTHO- CHLORONITROBENZENE IN RATS AND MICE
- Toxicity of Fire Decomposition Products of New Fire Extinguishing Agent, 1, 1, 1, 2, 3, 3, 3-Heptafluoropropane
- Carcinogenicity and Chronic Toxicity in Mice and Rats Administered Vinyl Acetate Monomer in Drinking Water
- Primary Osteosarcoma of the Lung : A Case Report
- Acute and Subchronic Inhalation Toxicity of Chloroform in Rats and Mice
- Characterization of Hydroxy-biphenyl-O-sulfates in Urine and Urine Crystals Induced by Biphenyl and KHCO_3 Administration in Rats
- Occurrence of two different types of glutathione S-transferase placental form-positive hepatocytes after a single administration of 2,3,7,8-tetrabromodibenzo-p-dioxin in rats
- DOSE- AND TIME-DEPENDENT EFFECTS OF 2,3,7,8-TETRABROMODIBENZO-P-DIOXIN ON RAT LIVER
- In vivo Rat Skin Micronucleus Induction of Glutaraldehyde.(GENERAL SESSION BY POSTER PRESENTATION)(GENOTOXICITY)
- P-37 Long-term Toxicology Study of 1, 4-Dioxane in the F344 Rats by Multiple-route Exposure : Drinking Water and Inhalation(Proceedings of the 27th Annual Meeting)
- P-36 Long-term Toxicology Study of Chloroform in the F344 Rats by Multiple-route Exposure : Drinking Water and Inhalation(Proceedings of the 27th Annual Meeting)
- Carcinogenicity and Chronic Toxicity of 1,4-Dichloro-2-nitrobenzene in Rats and Mice by Two Years Feeding
- Two-year Study of Carcinogenicity and Chronic Toxicity of p-Nitroanisole in Rats and Mice(Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Thirteen-Week Oral Toxicity Study of 1,4-Dichloro-2-Nitrobenzene in Rats and Mice (Special Issue: The Next Revolution in the Global Standardization of Occupational Vibration Prevention)
- Response to Dr. Bogdanffy et al.'s comments on our paper
- Carcinogenicity and Chronic Toxicity in Rats and Mice Exposed to Chloroform by Inhalation
- Two-year Study of Carcinogenicity and Chronic Toxicity of Biphenyl in Rats
- DYNAMICS OF ACTIVITY OF PROLYLHYDROXYLASE ASSAYED BY"KOSMART METHOD"IN COMPARED WITH HISTOLOGICAL ELUCIDATION IN TISSUE OF HEPATIC FIBROSIS INDUCED BY CARBON TETRACHLORIDE
- Thirteen-week Inhalation Toxicity of ρ-Dichlorobenzene in Mice and Rats
- Induction of Peroxisome Proliferation in the Liver of Biphenyl-Fed Female Mice
- Carcinogenicity and Chronic Toxicity after Inhalation Exposure of Rats and Mice to N,N-Dimethylformamide
- Toxicity due to 2- and 13-wk Inhalation Exposures of Rats and Mice to N,N-Dimethylformamide
- CLINICO-PATHOLOGICAL CHANGES INDUCED IN RATS TREATED WITH AMINE-CURING AGENT FOR EPOXY RESIN, BIS (4-AMINO-3-METHYLCYCLOHEXYL) METHANE
- Characterization of N-Acetylcysteine Conjugate in Yellow Urine by Oral Administration of 1,4-Dichloro-2-Nitrobenzene in Rats
- An Exposure System for Combined Administration of an Organic Solvent to Rodents by Inhalation and Water-Drinking and its Operational Performance
- Carcinogenicity and Chronic Toxicity in Mice and Rats Exposed by Inhalation to para-Dichlorobenzene for Two Years
- O-05 A new computerized prediction system of mutagenicity of chemicals(STATISTICAL AND TEST METHODS/GENERAL TOXICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- 21C-09-3 Micronucleus test using partially hepatectomized rat liver.
- Two-year Study of Carcinogenicity and Chronic Toxicity of Cyclohexene in Rats and Mice(Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Pulmonary toxicity of intratracheally instilled multiwall carbon nanotubes in male fischer 344 rats
- Carcinogenesis study of monochlorobenzene in the F344 rat (Inhalation study)
- Two- and 13-week Inhalation Toxicities of Indium-tin Oxide and Indium Oxide in Rats
- Inhalation Carcinogenicity and Chronic Toxicity of Indium-tin Oxide in Rats and Mice
- Pulmonary Toxicity in Mice by 2- and 13-week Inhalation Exposures to Indium-tin Oxide and Indium Oxide Aerosols
- ナノマテリアル最新情報(No.3)生体影響(その2)動物実験の現状と将来--吸入代替法(気管内投与)とその影響--多層カーボンナノチューブを例にして
- 1-クロロ-2, 4-ジニトロベンゼン(CDNB)のラット及びマウスを用いた経口投与によるがん原性試験
- p-クロロニトロベンゼン(p-CNB)のラット及びマウスを用いた経口投与によるがん原性試験
- ビフェニルのF344ラット及びBDF_1マウスへの長期投与による毒性
- 酢酸ビニルのF344ラット及びBDF_1マウスへの長期投与による毒性
- LONG TERM INHALATION TOXICITY STUDIES OF FIVE CHLORINATED HYDROCARBONS IN F344 RATS AND BDF1 MICE
- Genotoxicity and Cytotoxicity of Multi-wall Carbon Nanotubes in Cultured Chinese Hamster Lung Cells in Comparison with Chrysotile A Fibers
- A Pathological Study on Spontaneous Hepatic Neoplasms in BDF1 Mice.
- No carcinogenicity of ethyl tertiary-butyl ether by 2-year oral administration in rats
- P-032 多層カーボンナノチューブ(MWCNT)の肺胞マクロファージにおける小核誘発性 : ラットを用いた2週間及び13週間全身曝露吸入試験(I.変異原性・遺伝毒性,ポスターセッション)