Effects of Inhalation Exposure to Propylene Oxide on Respiratory Tract, Reproduction and Development in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Nasal, respiratory, reproductive and developmental toxicities of propylene oxide (PO) were examined by exposing male and female Sprague-Dawley rats to PO vapor by inhalation at a concentration of 0 (control), 125, 250, 500 or 1,000ppm for 6h/d, 7d/wk, during a 5- to 6-wk period, including premating, mating and postmating or gestation. The inhalation exposure to 1,000ppm PO seriously affected parental survival, the upper and lower respiratory tract, male and female reproductive systems, motor function, and fetal survival and development, whereas the exposure to 500ppm or less primarily caused nasal lesions without any sign of reproductive or developmental toxicity. Because atrophy of the olfactory epithelium in the male rats exposed to 250ppm was the most sensitive endpoint for PO toxicity, the NOAEL was determined to be 125ppm for the nasal endpoint. An additional inhalation experiment was carried out to further examine developmental toxicity by exposing pregnant rats to 0, 125, 250, 500, 750 or 1,000ppm PO during a 2-wk period of gestation, Day 6 through Day 19. The 2-wk inhalation experiment revealed that reduced fetal body weights and delayed ossification occurred in association with significantly reduced body weights of the dams exposed to 750 and 1,000ppm, whereas neither fetal death nor teratogenicity occurred at those two exposure levels. It was concluded that the developmental toxicity of fetal death was manifested at parentally toxic exposure levels above 500ppm, a level which seriously affected parental survival, the upper and lower respiratory tracts and reproductive system.
- 社団法人日本産業衛生学会の論文
著者
-
MATSUSHIMA Taijiro
Japan Bioassay Research Center
-
竹内 哲也
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
OKUDA Hirokazu
Japan Bioassay Research Center. Japan Industrial Safety and Health Association
-
Nagano Kasuke
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
-
Senoh Hideki
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Nagano Kasuke
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
長野 嘉介
Division Of Pathology Japan Bioassay Research Center
-
Nagano Kasuke
Japan Bioassay Research Center
-
Yamamoto Seigo
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Okuda Hirokazu
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
ARITO Heihachiro
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
-
Takeuchi Tetsuya
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Arito Heihachiro
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
-
Nagano K
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Senoh Hideki
Department Of Pathology Japan Bioassay Research Center
-
Senoh Hideki
中央労働災害防止協会日本バイオアッセイ研究センター
-
竹内 哲也
Division Of Pathology Japan Bioassay Research Center
-
Matsushima Taijiro
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Matsushima Taijiro
Japan Industrial Safety And Health Assoc. Kanagawa Jpn
-
Matsushima Taijiro
Japan Bioassay Laboratory
-
長野 嘉介
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Nagano Kasuke
中央労働災害防止協会日本バイオアッセイ研究センター
-
Okuda Hirokazu
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
関連論文
- Eradication of Helicobacter pylori induces apoptosis and inhibits proliferation of heterotopic proliferative glands in infected Mongolian gerbils
- β-Catenin gene alteration in glandular stomach adenocarcinomas in N-methyl-N-nitrosourea-treated and Helicobacter pylori-infected Mongolian gerbils
- β-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas
- Effect of early eradication on Helicobacter pyloirirelated gastric carcinogenesis in Mongolian gerbils
- Earlier Helicobacter pylori Infection Increases the Risk for the N-Methyl-N-nitrosourea-induced Stomach Carcinogenesis in Mongolian Gerbils
- Synergistic Promoting Effects of Helicobacter pylori Infection and High-salt Diet on Gastric Carcinogenesis in Mongolian Gerbils
- Reversibility of Heterotopic Proliferative Glands in Glandular Stomach of Helicobacter pylori-infected Mongolian Gerbils on Eradication
- Absence of β-catenin Mutations in Mouse Hepatoblastomas Induced by N,N-dimethylformamide
- Effects of Liver-Supplemented Food on the Development of Embryos in Mice
- Enhanced proliferative response of hepatocytes to combined inhalation and oral exposures to N,N-dimethylformamide in male rats
- Difference in Target Organs in Carcinogenesis with a Heterocyclic Amine, 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline, in Different Strains of Mice
- Incidence of Respiratory Metaplasia of the Nasal Gland Epithelium in Untreated F344 Rats and BDF1 Mice Subjected to Two-Year Carcinogenicity Studies
- Increased Incidence of Foreign Body Rhinitis in F344 Rats during Two-year Inhalation Exposure to Methyl Bromide
- Occurrence of Foreign Body Rhinitis in F344 Rats During Toxicologic Studies
- Enhanced hepatocarcinogenicity by combined inhalation and oral exposures to N,N-dimethylformamide in male rats
- Carcinogenicity and Chronic Toxicity in Rats and Mice Exposed by Inhalation to 1,2-Dichloroethane for Two Years
- Oral Carcinogenicity and Toxicity of 2-Amino-4-chlorophenol in Rats
- Design and performance of a system for blood collection of rats under whole-body inhalation exposure
- Identification of an N-acetylcysteine conjugate in the urine after oral administration of 2,4-dichloro-1-nitrobenzene to rats
- Thirteen-week oral toxicity of 1,4-dioxane in rats and mice
- Thirteen-week Inhalation Toxicity of Carbon Tetrachloride in Rats and Mice
- TIME-DEPENDENT INDUCTION OF MICRONUCLEATED HEPATOCYTES BY DIETHYLNITROSAMINE, 2-ACETYLAMINOFLUORENE AND MITOMYCIN C
- Effects of Inhalation Exposure to Propylene Oxide on Respiratory Tract, Reproduction and Development in Rats
- Developmental Toxicity Induced by Inhalation Exposure of Pregnant Rats to N,N-Dimethylacetamide
- Systemic and Myelotoxic Effects of Single Administration of 2, 3, 7, 8-Tetrabromodibenzo-p-Dioxin in Rats
- Adenoma of the Nasal Submucosal Glands in the BDF_1 Mouse : One Case among 2000 Controls in 2-year Carcinogenicity Studies
- O10-13 Reproductive and Developmental Toxicity of 1-bromopropane in Rats.
- P-35 Multiple-route Exposure Effects of Chloroform on Rat Liver Microsomes and Cytosols Activity(Proceedings of the 27th Annual Meeting)
- DEVELOPMENT OF RESISTANCE TO CHLOROFORM TOXICITY IN MALE BDF_1 MICE EXPOSED TO A STEPWISE INCREASE IN CHLOROFORM CONCENTRATION
- Inhalation Toxicology Studies of Chloroform in BDF_1 mice
- Micronuclei Induction of Methyl Bromide in Rats and Mice by Sub-chronic Inhalation Toxicity Test
- 211 ON AVAILABILITY OF HISTOGRAM AND RADARGRAN IN HEMATOLOGICAL AND BLOOD BIOCHEMICAL ANALYSIS FOR LONG TERN TOXICITY STUDIES
- Mutagenicity Study of Carbon Tetrachloride and Chloroform with Microbial Mutagenicity Test and Rat Liver Micronucleus Test
- A Pathological Study on Spontaneous Hepatic Neoplasms in BDF1 Mice
- TWO-YEAR FEED STUDY OF CARCINOGENICITY AND CHRONIC TOXICITY OF ORTHO-CHLORONITROBENZENE IN RATS AND MICE
- THIRTEEN-WEEK ORAL TOXICITY OF PARA- AND ORTHO- CHLORONITROBENZENE IN RATS AND MICE
- Carcinogenicity and Chronic Toxicity in Mice and Rats Administered Vinyl Acetate Monomer in Drinking Water
- Acute and Subchronic Inhalation Toxicity of Chloroform in Rats and Mice
- Characterization of Hydroxy-biphenyl-O-sulfates in Urine and Urine Crystals Induced by Biphenyl and KHCO_3 Administration in Rats
- Occurrence of two different types of glutathione S-transferase placental form-positive hepatocytes after a single administration of 2,3,7,8-tetrabromodibenzo-p-dioxin in rats
- DOSE- AND TIME-DEPENDENT EFFECTS OF 2,3,7,8-TETRABROMODIBENZO-P-DIOXIN ON RAT LIVER
- In vivo Rat Skin Micronucleus Induction of Glutaraldehyde.(GENERAL SESSION BY POSTER PRESENTATION)(GENOTOXICITY)
- P-37 Long-term Toxicology Study of 1, 4-Dioxane in the F344 Rats by Multiple-route Exposure : Drinking Water and Inhalation(Proceedings of the 27th Annual Meeting)
- P-36 Long-term Toxicology Study of Chloroform in the F344 Rats by Multiple-route Exposure : Drinking Water and Inhalation(Proceedings of the 27th Annual Meeting)
- Two-year Study of Carcinogenicity and Chronic Toxicity of p-Nitroanisole in Rats and Mice(Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Response to Dr. Bogdanffy et al.'s comments on our paper
- Carcinogenicity and Chronic Toxicity in Rats and Mice Exposed to Chloroform by Inhalation
- Two-year Study of Carcinogenicity and Chronic Toxicity of Biphenyl in Rats
- DYNAMICS OF ACTIVITY OF PROLYLHYDROXYLASE ASSAYED BY"KOSMART METHOD"IN COMPARED WITH HISTOLOGICAL ELUCIDATION IN TISSUE OF HEPATIC FIBROSIS INDUCED BY CARBON TETRACHLORIDE
- Thirteen-week Inhalation Toxicity of ρ-Dichlorobenzene in Mice and Rats
- Induction of Peroxisome Proliferation in the Liver of Biphenyl-Fed Female Mice
- Carcinogenicity and Chronic Toxicity after Inhalation Exposure of Rats and Mice to N,N-Dimethylformamide
- Toxicity due to 2- and 13-wk Inhalation Exposures of Rats and Mice to N,N-Dimethylformamide
- Characterization of N-Acetylcysteine Conjugate in Yellow Urine by Oral Administration of 1,4-Dichloro-2-Nitrobenzene in Rats
- An Exposure System for Combined Administration of an Organic Solvent to Rodents by Inhalation and Water-Drinking and its Operational Performance
- Cardiovascular malformations induced by prenatal exposure to phenobarbital in rats
- Carcinogenicity and Chronic Toxicity in Mice and Rats Exposed by Inhalation to para-Dichlorobenzene for Two Years
- O-05 A new computerized prediction system of mutagenicity of chemicals(STATISTICAL AND TEST METHODS/GENERAL TOXICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- 21C-09-3 Micronucleus test using partially hepatectomized rat liver.
- Two-year Study of Carcinogenicity and Chronic Toxicity of Cyclohexene in Rats and Mice(Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Carcinogenesis study of monochlorobenzene in the F344 rat (Inhalation study)
- Two- and 13-week Inhalation Toxicities of Indium-tin Oxide and Indium Oxide in Rats
- Inhalation Carcinogenicity and Chronic Toxicity of Indium-tin Oxide in Rats and Mice
- Pulmonary Toxicity in Mice by 2- and 13-week Inhalation Exposures to Indium-tin Oxide and Indium Oxide Aerosols
- LONG TERM INHALATION TOXICITY STUDIES OF FIVE CHLORINATED HYDROCARBONS IN F344 RATS AND BDF1 MICE
- Genotoxicity and Cytotoxicity of Multi-wall Carbon Nanotubes in Cultured Chinese Hamster Lung Cells in Comparison with Chrysotile A Fibers