DEVELOPMENT OF RESISTANCE TO CHLOROFORM TOXICITY IN MALE BDF_1 MICE EXPOSED TO A STEPWISE INCREASE IN CHLOROFORM CONCENTRATION
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the development of resistance to chloroform toxicity, a 4-week inhalation study was conducted in which BDF_1 male mice were exposed to a low level of chloroform for an initial two-week period, and thereafter the exposure concentration was increased for a second two-week period. The animals were exposed to inhalation of chloroform vapor 6 hr per day, 5 days per week, with clinical observation and measurement of body weight conducted. These results demonstrate that pre-exposure to chloroform at a low dose level induced resistance to a higher dose of chloroform in male mice. This resistance was dependent on the pre-exposure concentration.
- 日本トキシコロジー学会の論文
- 1999-12-20
著者
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MATSUSHIMA Taijiro
Japan Bioassay Research Center
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竹内 哲也
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Aiso Shigetoshi
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Nagano Kasuke
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Nagano Kasuke
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Nagano Kasuke
Japan Bioassay Research Center
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Yamamoto Seigo
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Kasai Tatsuya
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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NISHIZAWA Tomoshi
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Takeuchi Tetsuya
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Katagiri Taku
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Aiso Shigetoshi
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Aiso Shigetoshi
Division Of Pathology Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Nishizawa Tomoshi
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Nagano K
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Kasai Tatsuya
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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竹内 哲也
Division Of Pathology Japan Bioassay Research Center
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Noguchi Tadashi
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Noguchi Tadashi
Japan Bioassay Research Center
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相磯 成敏
Division Of Pathology Japan Bioassay Research Center
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Matsushima Taijiro
Japan Bioassay Laboratory
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Kasai Tatsuya
中央労働災害防止協会日本バイオアッセイ研究センター
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長野 嘉介
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Aiso Shigetoshi
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
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