Threshold for Genotoxic Carcinogens : The Central Concern in Carcinogenic Risk Assessment
スポンサーリンク
概要
著者
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Wei Min
大阪府立成人病センター 分子生物学
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Kinoshita Anna
Department Of Pathology Osaka City University Medical School
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Fujiwara Yushi
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
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Fukushima Shoji
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
関連論文
- Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
- N-Methyl-N-nitrosourea Concentration-dependent, Rather than Total Intake-dependent, Induction of Adenocarcinomas in the Glandular Stomach of BALB/c Mice
- Surgical Resection for Ruptured Aneurysm of Middle Colic Artery Caused by Segmental Arterial Mediolysis : A Case Report
- Absence of β-catenin Mutations in Mouse Hepatoblastomas Induced by N,N-dimethylformamide
- Carcinogenic Potential of 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) in Severe Combined Immunodeficient (SCID) Mice
- Lack of Inhibition of BBN-induced Bladder Carcinogenesis in C57BL/6 Mice by Intravesical Instillation of KRN 7000
- Reliability Evaluation of the Mediumterm Liver Bioassay Based on Long-term Feeding Study Results for Phenobarbital with Reference to the Dose-response
- P6-02 Enhancement of thioacetamide-induced liver cirrhosis by estradiol 3-benzoate in the rats(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Carcinogenicity of Dimethylarsinic Acid in F344 Rats and p53 (+/-) Knockout and Wild Type C57BL/6J Mice. Relevance with Genetic Alterations and Oxidative DNA Damage (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual
- Significance of Cyclin D1 Overexpression in Transitional Cell Carcinomas of the Urinary Bladder and its Correlation with Histopathological Features
- Establishment and characterization of a human colonic mucinous carcinoma cell line with predominant goblet-cell differentiation from liver metastasis
- Existence of a no effect level for MeIQx hepatocarcinogenicity on a background of thioacetamide-induced liver damage in rats
- Differences in Sensitivity of F344 Rats from Different Breeders to Phenobarbital Hepatocarcinogenicity
- Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis
- Promoting Effect of Sodium L-Ascorbate on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Renal Pelvic Carcinogenesis in SD/cShi Rats of Both Sexes
- Lack of changes in the levels of liver and kidney cytochrome P-450 isozymes in p53(+/-)knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
- Differences among Three Sister Strains of NON/Shi Mice in Sensitivity to Urinary Tract Carcinogenesis by N-Butyl-N-(4-hydroxybutyl)nitrosamine.
- High Susceptibility of p53(+/-)Knockout Mice in N-Butyl-N-(4-hydroxybutyl)nitrosamine Urinary Bladder Carcinogenesis and Lack of Frequent Mutation in Residual Allele.
- Di-n-butyl Phthalate is Toxic to the Male Reproductive System and Its Toxicity is Enhanced by Thioacetamide Induced Liver Injury
- Food Restriction Inhibits the Growth of Intestinal Polyps in Multiple Intestinal Neoplasia Mouse
- Chemopreventive Effects of Coumaperine from Pepper on the Initiation Stage of Chemical Hepatocarcinogenesis in the Rat
- Enhanced proliferative response of hepatocytes to combined inhalation and oral exposures to N,N-dimethylformamide in male rats
- Possible Involvement of Adaptation Mechanisms in the Achievement of an Ineffective Dose Range for the Carcinogenicity of Genotoxic Carcinogens
- Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline (MeIQx) in rats
- Promotion of Rat Hepatocarcinogenesis by Dimethylarsinic Acid : Association with Elevated Ornithine Decarboxylase Activity and Formation of 8-Hydroxydeoxyguanosine in the Liver
- p53 and H-ras Mutations and Microsatellite Instability in Renal Pelvic Carcinomas of NON/Shi Mice Treated with N-Butyl-N-(4-hydroxybutyl)-nitrosamine: Different Genetic Alteration from Urinary Bladder Carcinoma
- Inhibitory Effects of S-Methylcysteine and Cysteine on the Promoting Potential of Sodium Phenobarbital on Rat Liver Carcinogenesis
- p53 in Multiple Human Urothelial Cancers: Assessment for Clonality by the Yeast p53 Functional Assay in Combination with p53 Immunohistochemistry
- Loss of Heterozygosity in (Lewis×F344)F_1 Rat Urinary Bladder Tumors Induced with N-Butyl-N-(4-hydroxybutyl) nitrosamine Followed by Dimethylarsinic Acid or Sodium L-Ascorbate
- Molecular cytogenetic identification of cyclin D1 gene amplification in a renal pelvic tumor attributed to phenacetin abuse
- Urinary Bladder Lesions after the Chernobyl Accident : Immunohistochemical Assessment of p53, Proliferating Cell Nuclear Antigen, Cyclin D1 and p21^
- Promotion by Sodium L-Ascorbate in Rat Two-stage Urinary Bladder Carcinogenesis is Dependent on the Interval of Administration
- Cyclin D1 Overexpression in Rat Two-Stage Bladder Carcinogenesis and its Relationship with Oncogenes, Tumor Suppressor Genesand Cell Proliferation
- Inhibition of Development of N,N'-Dimethylhydrazine-induced Rat Colonic Aberrant Crypt Foci by Pre, Post and Simultaneous Treatments with 24R ,25-Dihydroxyvitamin D_3
- Susceptibility of Four F_1 Hybrids of Male Rats to the Promoting Effects of Sodium L-ascorbate in Two-Stage Urinary Bladder Carcinogenesis
- Enhanced hepatocarcinogenicity by combined inhalation and oral exposures to N,N-dimethylformamide in male rats
- P081 Chemopreventive effects of Tamarind (Tamarindus indica L) husk extract on the early stages of rat hepatocarcinogenesis
- O-04 Chemopreventive effects of Tamarind (Tamarindus indica L) husk extract on the early stages of rat hepatocarcinogenesis(ACEM Oral Presentation I)
- Chemopreventive Effects of Bovine Lactoferrin on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Rat Bladder Carcinogenesis
- Oral Carcinogenicity and Toxicity of 2-Amino-4-chlorophenol in Rats
- Design and performance of a system for blood collection of rats under whole-body inhalation exposure
- Identification of an N-acetylcysteine conjugate in the urine after oral administration of 2,4-dichloro-1-nitrobenzene to rats
- Thirteen-week oral toxicity of 1,4-dioxane in rats and mice
- Thirteen-week Inhalation Toxicity of Carbon Tetrachloride in Rats and Mice
- Existence of a Threshold for the Genotoxic Carcinogens : Evidence from Mechanism-based Carcinogenicity Studies
- Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident
- Hormesis in Carcinogenicity of Non-genotoxic Carcinogens
- Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis
- Aberrant expression of E-cadherin and β-catenin in association with transforming growth factor-β1 in urinary bladder lesions in humans after the Chernobyl accident
- Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol : Evidence for a threshold
- Examination of the Rat Model of Liver Injury via Thioacetamide (TAA) or Carbon Tetrachloride (CCl_4)
- Significance of overexpression of metallothionein in mouse urinary bladder focal lesions induced by treatment with N-butyl-N-(4-hydroxybutyl)-nitrosamine
- Biphasic Increase of Epithelial DNA Synthesis in the Urinary Bladder of Rats Treated with a Tumor Promoter, Sodium L-ascorbate
- Influence of Strain and Diet on Hepatocarcinogenicity of N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in Rats : Slight Inhibition of Preneoplastic Liver Lesion Development by Uracil
- Urinary bladder lesions induced by persistent chronic low-dose ionizing radiation
- Lack of Inhibitory Effects of an Anti-angiogenesis Drug, TNP-470, on Rat Urinary Bladder Papillomatosis Induced by Mechanical Stimulation
- Esophageal tuberculosis presenting with an appearance similar to that of carcinoma of the esophagus
- Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in Keratin (K6)/ODC Transgenic Mice
- Efficiency of Rebamipide in the Prevention of Remnant Gastritis after Distal Gastrectomy
- Carcinogenicity of Methylurea or Morpholine in Combination with Sodium Nitrite in a Rat Multi-organ Carcinogenesis Bioassay
- Lack of Promoting Effects of α-Linolenic, Linoleic or Palmitic Acid on Urinary Bladder Carcinogenesis in Rats
- Self-Expandable Metallic Stent for Unresectable Malignant Strictures in the Esophagus and Cardia
- RELIABILITY AND PRACTICALITY OF MEDIUM-TERM CARCINOGENESIS BIOASSAYS(WORKSHOP 4 : NEW TECHNOLOGY AND EVALUATIONS OF IN VIVO TOXICITY STUDIES)
- Lack of Inhibitory Effects of Coumaperine from Pepper on the Promotion Stage of Chemical Hepatocarcinogenesis in the Rat
- DOSE-RELATED INCREASES IN QUANTITATIVE VALUES FOR GLUTATHIONE S-TRANSFERASE PLACENTAL FORM (GST-P) POSITIVE FOCI AND CYTOCHROME P-450 LEVELS IN THE LIVER OF F344 RATS EXPOSED TO PHENOBARBITAL SODIUM (PB) IN A MEDIUM-TERM BIOASSAY
- Isolation of Differentiated Squamous and Undifferentiated Spindle Carcinoma Cell Lines with Differing Metastatic Potential from a 4-Nitroquinoline N-Oxide-induced Tongue Carcinoma in a F344 Rat
- Inhibitory effect of phenobarbital at low dose on rat hepatocarcinogenesis : the evidence for hormesis (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Thresholds for Carcinogenicity of Environmental Carcinogens (SYMPOSIUM3: RECENT TOPICS ON THE RISK ASSESSMENT OF CHEMICAL CARCINOGENS) (Proceedings of the 30th Annual Meeting)
- Lack of Influence of Testicular Castration or Sialoadenectomy on Sodium L-Ascorbate Promotion of Urinary Bladder Carcinogenesis in Male F344 Rats
- Strain Differences in Sensitivity to the Promoting Effect of Sodium L-Ascorbate in a Two-stage Rat Urinary Bladder Carcinogenesis Model
- Characteristic Upregulation of Glucose-Regulated Protein 78 in an Early Lesion Negative for Hitherto Established Cytochemical Markers in Rat Hepatocarcinogenesis
- Ambulatory intraesophageal bilirubin monitoring in Japanese patients with gastroesophageal reflux
- INHIBITING EFFECTS OF DIETHYLMALEATE OR NH_4Cl ON NaHCO_3, BUT NOT BUTYLATED HYDROXYANISOLE, PROMOTION OF URINARY BLADDER CARCINOGENESIS IN MALE F344 RATS INITIATED WITH N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE
- Lack of Enhanced Epithelial Cell Proliferation in the Urinary Bladder of Heterozygous p53 Knockout Mice Given Sodium Ortho-phenylphenate or Uracil
- Are tobacco use and urine pH indicated as risk factors for bladder carcinoma?
- Overexpression of Cyclin D1 in Rat Esophageal Carcinogenesis Model
- Low susceptibility of nude mice to induction of invasive urinary bladder cancers by N-Ethyl-N-(4-hydroxybutyl) nitrosamine (EHBN).
- LACK OF INHIBITORY EFFECTS OF THE JU-MYO PROTEIN ON DEVELOPMENT OF GLUTATHIONE S-TRANSFERASE PLACENTAL FORM-POSITIVE FOCI IN THE MALE F344 RAT LIVER
- Thoracoscopic Esophagectomy for Intrathoracic Esophageal Cancer
- S-Methylcysteine and Cysteine Are Inhibitors of Induction of Glutathione S-Transferase Placental Form-positive Foci during Initiation and Promotion Phases of Rat Hepatocarcinogenesis
- Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay: Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of P53 on Urinary Bladder Carcinogenesis
- Two- and 13-week Inhalation Toxicities of Indium-tin Oxide and Indium Oxide in Rats
- Inhalation Carcinogenicity and Chronic Toxicity of Indium-tin Oxide in Rats and Mice
- Pulmonary Toxicity in Mice by 2- and 13-week Inhalation Exposures to Indium-tin Oxide and Indium Oxide Aerosols
- Modified Triangulating Stapling Technique for Closure of a Temporary Loop Stoma
- Granulocyte Colony-stimulating Factor-producing Ascending Colon Cancer as Indicated by Histopathological Findings : Report of a Case
- Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in rats : Evidence for the existence of no-effect levels and a mechanism involving p21^
- AGR2 as a Potential Biomarker of Human Lung Adenocarcinoma
- Threshold for Genotoxic Carcinogens : The Central Concern in Carcinogenic Risk Assessment
- Genotoxicity and Cytotoxicity of Multi-wall Carbon Nanotubes in Cultured Chinese Hamster Lung Cells in Comparison with Chrysotile A Fibers
- Differences Among Three Sister Strains of NON/Shi Mice in Sensitivity to Urinary Tract Carcinogenesis by N-Butyl-N-(4-hydroxybutyl)nitrosamine
- Lack of Promoting Potential of Dimethylarsinic Acid in the Kidney of Male NCI-Black Reiter Rats
- Susceptibility of Male WS/Shi Rats to Melamine but not NaHCO_3 or Butylated Hydroxyanisole Promotion of Urinary Bladder Carcinogenesis
- Characteristic Upregulation of Glucose-Regulated Protein 78 in an Early Lesion Negative for Hitherto Established Cytochemical Markers in Rat Hepatocarcinogenesis
- Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker
- Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay : Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of p53 on Urinary Bladder Carcinogenesis
- Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats
- Morphological Changes in Silver-stained Nucleolar Organizer Regions (AgNORs) Related to Proliferative Activity in Glutathione S-transferase Placental Form (GST-P) Positive Foci of Rat Liver
- Threshold for Genotoxic Carcinogens : The Central Concern in Carcinogenic Risk Assessment
- Lymphoid hyperplasia detected as a single mass in the gallbladder : report of a case