Tamsulosin: α_1 : Adrenoceptor Subtype : Selectivity and Comparison With Terazosin
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概要
- 論文の詳細を見る
Selectivity of tamsulosin and terazosin to functional α1-adrenoceptors was examined. Both drugs competitively inhibited the contractile responses to noradrenaline in different tissues where the responses were mediated through the α1D-, α1B- or α1L-subtype. Together with the affinities obtained in the binding study with cloned (α1a, α1b, α1d) and native (α1A and α1B) subtypes, the selectivity of tamsulosin was α1A>α1L, α1D>α1B. Terazosin had lower affinity at various subtypes than tamsulosin, but showed relatively high selectivity to the α1D-subtype. In the human prostate, tamsulosin was more than 30-fold higher in affinity than terazosin in functional and binding studies.
- 社団法人 日本薬理学会の論文
- 1998-11-01
著者
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Okada Kenichiro
Urology School Of Medicine Fukui Medical University
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TANIGUCHI Takanobu
Department of Biochemistry, Asahikawa Medical College
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MURAMATSU IKUNOBU
Department of Pharmacology, Fukui Medical School
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Muramatsu Ikunobu
Department Of Pharmacology Faculty Of Medicine Kyoto University And Department Of Zoology And Its Ca
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Muramatsu Ikunobu
Departments Of Pharmacology
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Taniguchi Takanobu
Department Of Biochemistry Asahikawa Medical College
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Taniguchi Takanobu
Departments Of Pharmacology
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