Tizanidine May Discriminate between Imidazoline-Receptors and .ALPHA.2-Adrenoceptors.
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概要
- 論文の詳細を見る
The selectivity of tizanidine to the imidazoline-receptor and α<SUB>2</SUB>-adrenoceptor recognized by <SUP>3</SUP>H-<I>p</I>-aminoclonidine was examined in rat kidney membranes and was compared with those of other imidazoline compounds. Tizanidine bound to the imidazoline-receptors with approximately 20 times higher affinity than the α<SUB>2</SUB>-adrenoceptors. The order of relative selectivity to imidazoline receptor was tizanidine > oxymetazoline > clonidine > naphazoline, where clonidine showed an equal affinity to both receptors. Tizanidine may act more potently on the imidazoline-receptors than the α<SUB>2</SUB>-adrenoceptors.
- 公益社団法人 日本薬理学会の論文
著者
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Muramatsu Ikunobu
Department Of Pharmacology Faculty Of Medicine Kyoto University And Department Of Zoology And Its Ca
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Kigoshi Shigeru
Department Of Pharmacology Fukui Medical School
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