Dissociation between sympathetic purinergic response and ATP response in the mesenteric artery of the dog.
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概要
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In the presence of prazosin and propranolol, electrical transmural stimulation of isolated dog mesenteric artery produced a sympathetic purinergic contraction, which was followed by a relaxation in PGF<SUB>2α</SUB>-contracted arteries. Such purinergic responses were mimicked by brief exposure to α, β-methylene ATP (α, β-Me ATP) and were completely inhibited after desensitization of P<SUB>2x</SUB>-purinergic receptors. However, exogenous ATP predominantly evoked a relaxation in PGF<SUB>2α</SUB>-contracted artery. These results suggest that the sympathetic purinergic response may be caused by a P<SUB>2x</SUB>-purinergic receptor-selective mechanism or substance, rather than ATP.
- 公益社団法人 日本薬理学会の論文
著者
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Muramatsu Ikunobu
Department Of Pharmacology Faculty Of Medicine Kyoto University And Department Of Zoology And Its Ca
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Oda Yasuo
Faculty Of Pharmaceutical Sciences Kinki University
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Kigoshi Shigeru
Department Of Pharmacology Fukui Medical School
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