Syntheses of Derivatives of the Trisaccharide GlcNAcβ1→2Manα1→3Man

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概要

• 論文の詳細を見る

• The glycosphingolipids isolated from spermatozoa of a fresh-water bivalve, Hyriopsis schlegelii, have a unique structure containing one or two mannosyl residues. We synthesized the trisaccharide derivatives which constitute the partial structure of lipid I and/or II. Condensation of 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl bromide with methyl 3-O-benzyl-4,6-O-benzylidene-α-D-mannopyranoside in the presence of mercuric cyanide gave methyl 3-O-benzyl-4,6-O-benzylidene-2-O-(3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)-α-D-mannopyranoside in 80% yield. Condensation of the disaccharide bromide with the appropriate C-3 hydroxyl free mannose derivatives afforded the corresponding GlcNAcβ1→2Manα1→3Man derivatives (11 and 12).

• 公益社団法人日本薬学会の論文
• 1985-02-25

著者

• 荻原 幸夫

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 荻原 幸夫

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 竹田 忠紘

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Takeda T

  Kyoritsu University Of Pharmacy

• 藤沢 慎一

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 堀 太郎

  Department of Chemistry, Faculty of Liberal Arts and Education, Shiga University

• 堀 太郎

  Department Of Chemistry Faculty Of Liberal Arts And Education Shiga University

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