Syntheses of New Model Compounds Related to an Antigenic Epitope from Bupleurum falcatum L. and Their Distributions in Various Ganglioside-Phospholipid Monolayers
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概要
- 論文の詳細を見る
6-N-[2-(Tetradecyl)hexadecanamido] hexyl β-D-glucopyranosyluronic acid-(1→6)-β-D-galactopyranosyl-(1→6)-β-D-galactopyranoside (1) and its clustering compound (2) carrying a tetravalent sugar unit, which are new model compounds related to a major antigenic epitope from antiulcer pectic polysaccharide of Bupleurum falcatum L., were synthesized and the distributions of 1 and 2 in mixed ganglioside (GM1, GD1a or GT1b)/phospholipid (DPPC) monolayers were observed using atomic force microscopy (AFM). AFM images showed that 1 was distributed in the GM1, GD1a and GT1b region of the mixed monolayers, in which 1 was miscible with GD1a. Specific distribution of 1 was observed in the mixed GM1/DPPC monolayer. Compound 2 was miscible with GM1, while 2 formed associations with GD1a and GT1b in the mixed monolayers. The distribution mode of 1 and 2 was different among the mixed ganglioside/DPPC monolayers.
- 公益社団法人日本薬学会の論文
- 2006-09-01
著者
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TAKEDA Tadahiro
Kyoritsu University of Pharmacy
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竹田 忠紘
Kyoritsu College Of Pharmacy
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竹田 忠紘
Faculty Of Pharmaceutical Sciences Nagoya City University
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Taguchi Tomiko
Laboratory Of Plant Pathology And Genetic Engineering Faculty Of Agriculture Okayama University
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HADA Noriyasu
Kyoritsu College of Pharmacy
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Hada N
Kyoritsu University Of Pharmacy
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Ohtsuka Isao
Kyushu University Of Health And Welfare
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JIN Yuhua
Kyoritsu University of Pharmacy
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Yokoyama Shoko
Kyushu University Of Health And Welfare
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Takeda T
Kyoritsu University Of Pharmacy
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Takeda Tadahiro
Kyoritsu College Of Pharmacy
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Takeda Tadahiro
Kyoritsu College Of Pharmac
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