Synthetic Studies on Glycosphingolipids from Protostomia Phyla : Synthesis of a Glycosphingolipid Analogue from the Parasite Spirometra erinacei
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概要
- 論文の詳細を見る
Novel neutral glycosphingolipids isolated from the plerocercoids of a tapeworm, Spirometra erinacei, may be expected to be involved in host-parasite interactions. We have synthesized this glycosphingolipid analogue containing 2-branched fatty alkyl residue in place of ceramide. Glycosylation of nonreducing-end trisaccharide derivative 15 with the reducing-end disaccharide derivative 17 in the presence of trimethylsilyl triflate (TMSOTf) gave the desired oligosaccharide derivative in good yield. The fully per-O-acylated 2-(trimethylsilyl)ethyl glycoside 19 was converted to glycosylimidate 20,which was condensed with 2-(tetradecyl)hexadecanol and subsequently deacylated to give the target glycosphingolipid analogue 22.
- 公益社団法人日本薬学会の論文
- 2000-08-01
著者
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HADA Noriyasu
Kyoritsu College of Pharmacy
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Takeda Tadahiro
Kyoritsu College Of Pharmac
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KURODA Mayuko
Kyoritsu College of Pharmacy
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