Further Studies on the Structure of Polysaccharides from the Bark of Melia azadirachta

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概要

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• Water-soluble polysaccharides, designated as GIIa and GIIIa, were isolated together with GIa and GIb from the bark of Melia azadirachta (Meliaceae), and their anti-inflammatory effect on carrageenan-induced edema was tested. GIIa and GIIIa each gave a single peak on high-performance liquid chromatography and gel filtration. Methylation, periodate oxidation and carbon-13 nuclear magnetic resonance spectroscopic studies suggested that GIIa is composed of the following repeating unit : α-D-G1c1→4α-D-G1c1→3α-D-G1c1→3α-D-G1c6←1α-L-ArafGIIIa is [numbrical formula] a branched arabinofucoglucan containing a main chain of 1→4-linked α-D-glucopyranosyl units substituted in the 6 position with side chains of α-L-arabinofuranose and β-L-fucopyranose.

• 社団法人日本薬学会の論文
• 1984-04-25

著者

• 清水 正樹

  テルモ(株)

• 荻原 幸夫

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 荻原 幸夫

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 竹田 忠紘

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 清水 正樹

  Technical R and D Division, Terumo Co., Ltd.,

• 野村 武男

  Technical R and D Division, Terumo Co., Ltd.

• 冨田 裕

  Technical R and D Division, Terumo Co., Ltd.

• 藤原 忠美

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 杉下 悦子

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 野村 武男

  Technical R And D Division Terumo Co. Ltd.

• 冨田 裕

  Technical R And D Division Terumo Co. Ltd.

• 藤原 忠美

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 杉下 悦子

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Takeda T

  Kyoritsu University Of Pharmacy

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