Chemoenzymatic Synthesis of n-Hexyl and ο-β-D-Xylopyranosyl-(1→6)-β-D-glucopyranosides
スポンサーリンク
概要
- 論文の詳細を見る
Direct β-glucosidation between 1,6-octanediol (5) and D-glucose (3) using the immobilized β-glucosidase (EC 3.2.1.21) from almonds with the synthetic prepolymer ENTP-4000 gave a mono-β-glucoside (6) in 61.4% yield, which was converted into the n-hexyl β-D-glucopyranoside (1) by means of a chemoenzymatic method. The coupling of the n-hexyl β-D-glucopyranoside congener (13) and 2,3,4-tri-O-acetyl-)β-D-xylosyl congener (14), followed by deprotection, afforded the synthetic n-hexyl O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside (2), which was identical to the natural 2 with respect to the spectral data and specific rotation.
- 公益社団法人日本薬学会の論文
- 2004-09-01
著者
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AKITA Hiroyuki
School of Pharmaceutical Science, Toho University
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Kato K
School Of Pharmaceutical Sciences Toho University
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Kato Keisuke
School Of Pharmaceutical Sciences Toho University
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Nishiuchi Masaki
Department Of Chemical Science And Technology Faculty Of Engineering The University Of Tokushima
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Akita Hiroyuki
School Of Parmaceutical Sciences Toho University
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Kawachi M
School Of Pharmaceutical Sciences Toho University:tsukuba Research Institute Novartis Pharma K. K.
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Nishiuchi M
School Of Pharmaceutical Sciences Toho University
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KISHIDA Masashi
School of Pharmaceutical Sciences, Toho University
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NISHIUCHI Miho
School of Pharmaceutical Sciences, Toho University
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Kato Keisuke
School Of Pharmaceutical Science Toho University
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