Reaction of Methyl 4,5-Epoxy-(2E)-pentenoate with Arylcopper Reagents
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概要
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The reaction of methyl 4,5-epoxy-(2E)-pentenoate (1) with various arylcopper reagents was studied. Basically, all arylcopper reagents react with 1 in SN2 fashion. However, addition of BF_3 causes reversal of the regioselectivity, which can be rationalized in terms of a two-step conversion by way of methyl 4-bromo-5-hydroxy-2-pentenoate (5).
- 公益社団法人日本薬学会の論文
- 1996-04-15
著者
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Nagumo Shinji
School Of Pharmaceutical Science Toho University
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AKITA Hiroyuki
School of Pharmaceutical Science, Toho University
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IRIE Shigeyuki
School of Pharmaceutical Science, Toho University
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Irie Shigeyuki
School Of Pharmaceutical Science Toho University
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Akita Hiroyuki
School Of Parmaceutical Sciences Toho University
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