Photodegradation Products of a New Antibacterial Fluoroquinolone Derivative, Orbifloxacin, in Aqueous Solution

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概要

• 論文の詳細を見る

• A new antibacterial fluoroquinolone derivative, orbifloxacin (ORFX), is decomposed photochemically in aqueous solution. When ORFX solution was irradiated with a chemical lamp or sunlight, three major photodegradation products were isolated by preparative HPLC. These degradation products were identified by electron-impact mass spectrometry, liquid-secondary-ion mass spectrometry and ^1H-NMR spectroscopy.Moreover, the photodegradation pathway was investigated by a similar study using several fluoroquinolone derivatives which were presumed to be the intermediates of the photorection of ORFX. consequently, it was found that two main photochemical reactins, the decomposition of the dimethylpiperazinyl moiety and the elimination of the cyclopropyl group, take place in ORFX. The detected structures of photodegradation products and the photodegradation studies of the postulated intermediates suggested that the photodecomposition of the dimethylpiperazinyl ring at the 7-position and the elimination of the cyclopropyl group at the 1-position occurred concurrently with the release of fluorine at the 8-position.

• 公益社団法人日本薬学会の論文
• 1997-02-15

著者

• Matsukura H

  Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt

• MORIMURA Tetsu

  Department of Chemical Analysis, Pharmaceutical Research Laboratories, Dainippon Pharmaceutical Co.,

• NOBUHARA Yoshifumi

  Department of Chemical Analysis, Pharmaceutical Research Laboratories, Dainippon Pharmaceutical Co.,

• MATSUKURA Hayashi

  Department of Chemical Analysis, Pharmaceutical Research Laboratories, Dainippon Pharmaceutical Co.,

• 森村 徹

  Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt

• 延原 好文

  Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt

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