Effect of the Selective Adenosine A_1-Receptor Antagonist KW-3902 on Tubuloglomerular Feedback in Radiocontrast-Media-Induced Nephropathy in Rats With Chronic Nitric Oxide Deficiency
スポンサーリンク
概要
- 論文の詳細を見る
To study the possible mechanism of renoprotective effects of adenosine A1-receptor antagonist against radiocontrast media (RCM)-induced nephropathy, we investigated the effects of adenosine A1-receptor antagonist on tubuloglomerular feedback (TGF) activity prior to and following application of RCM in chronic NO-depleted rats. TGF in NO-depleted rats was significantly enhanced compared with that in normal rats. After RCM application, the enhanced TGF was continued. A selective adenosine A1-receptor antagonist, KW-3902 (8-(noradamantan-3-yl)-1, 3-dipropylxanthine), inhibited the enhanced TGF. These results suggest that KW-3902 could inhibit TGF in chronic NO-depleted rats. Renoprotective effects by adenosine antagonists could be partly due to an inhibition of TGF via the blockade of the adenosine A1-receptor.
- 社団法人 日本薬理学会の論文
- 2000-11-01
著者
-
YAO Kozo
Drug Department Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd
-
Yao Kozo
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
-
HEYNE Nils
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Lt
-
OSSWALD Hartmut
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Lt
-
Heyne Nils
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
-
Osswald Hartmut
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
関連論文
- Effect of the Selective Adenosine A_1-Receptor Antagonist KW-3902 on Lipopolysaccharide-Induced Reductions in Urine Volume and Renal Blood Flow in Anesthetized Dogs
- Effect of the Selective Adenosine A_1-Receptor Antagonist KW-3902 on Tubuloglomerular Feedback in Radiocontrast-Media-Induced Nephropathy in Rats With Chronic Nitric Oxide Deficiency
- Antioxidant Effects of Calcium Antagonists in Rat Brain Homogenates