Quantitative Analyses of Lymphoid Tissue in the Spleen, Lymph Nodes, and Peyers Patches in Cynomolgus Monkeys

概要

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To clarify the morphological characteristics of the cynomolgus monkey immune system, we analyzed quantitative data on their lymphoid organs. Spleens, major lymph nodes, and Peyers patches were sampled from cynomolgus monkeys, and the lymphoid follicle and germinal center areas and percentages of CD3- and CD20-positive areas were calculated. All the organs analyzed showed large interindividual variations in the sizes of lymphoid follicles and germinal centers. The lymphoid follicles and germinal centers were largest in the spleen; but those in the lymph nodes and Peyers patches showed no marked difference in size. Areas containing T cells were largest in the lymph nodes, while those containing B cells were largest in the spleen and Peyers patches. The mean size of the splenic lymphoid follicle in cynomolgus monkeys is larger than that in rats, and similar to that in humans. It is important to use cynomolgus monkeys in standard toxicity studies, based on large individual variation and the characteristics of lymphoid organs. Taking advantage of the characteristics of each species enables reliable evaluation of the immunologic system in standard toxicity studies.