Data on Wistar Hannover Rats from a General Toxicity Study

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概要

• 論文の詳細を見る

• The aim of this study was to collect data on chronological changes in clinical laboratory tests, pathological examinations, and hepatic drug-metabolizing enzymes from Wistar Hannover rats at 8, 10, 19, and 32 weeks of age. The serum triglyceride concentration and the serum LDL cholesterol level were higher in males than in females at all ages. In contrast, serum total protein and creatinine concentrations and cholinesterase activity were lower in males than in females. In addition, sex differences were confirmed in pituitary weight and hepatic CYP3A2 and CYP2C11 activities. In conclusion, the general toxicological data noted in clinical laboratory tests, pathological examinations, and hepatic drug-metabolizing enzymes relating to chronological changes and sex differences may be useful in assessing drug-related toxicity in this strain.

• Japanese Association for Laboratory Animal Scienceの論文

著者

• Shiraishi Mitsuya

  The United Graduate School Of Veterinary Science Yamaguchi University

• YAMATOYA Hideyuki

  The United Graduate School of Veterinary Science, Yamaguchi University

• YAMASHITA Rie

  Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd. (SNBL DSR)

• MIYOSHI Noriaki

  The United Graduate School of Veterinary Science, Yamaguchi University

• Kadokura Hidetomi

  Drug Safety Research Laboratories Shin Nippon Biomedical Laboratories Ltd. (snbl Dsr)

• Yoshikawa Tsuyoshi

  Drug Safety Res. Laboratories Shin Nippon Biomedical Laboratories Ltd.

• Miyamoto Atsushi

  The United Graduate School Of Veterinary Science Yamaguchi University

• Kawaguchi Hiroaki

  The United Graduate School Of Veterinary Science Yamaguchi University

• Yajima Kanako

  Pharmacokinetics And Bioanalysis Center Shin Nippon Biomedical Laboratories Ltd.

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