Pathological Effects in Lymphoid Tissues of the Spleen, Lymph Nodes, and Peyer’s Patches in Cyclosporin-Treated Cynomolgus Monkeys
スポンサーリンク
概要
- 論文の詳細を見る
Germinal center/lymphoid follicle area ratio and CD3/CD20-positive area ratio were calculated for the spleen, submandibular and mesenteric lymph nodes, and Peyer’s patches in cynomolgus monkeys treated orally with cyclosporin A (CsA), an immunosuppressant which blocks Ca2+/NFAT signaling. A difference in hypocellularity between lymphoid organs was observed after CsA administration in a dose-dependent manner. Regarding drug efficacy, the highest susceptibility to CsA tended to be shown in the Peyer’s patches, and susceptibility then descended in the order of the spleen, mesenteric lymph nodes, and submandibular lymph nodes. It was shown in the present study that decreases in germinal center area and CD3-positive area were sensitive indicators of the efficacy of CsA for lymphoid organs and tissue in cynomolgus monkeys.
著者
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MAEDA Hiroshi
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Lt
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Hirai Takuya
Department Of Veterinary Pathology Faculty Of Agriculture University Of Miyazaki
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MORIYAMA Akiko
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.
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HIRAI Takuya
The United Graduate School of Veterinary Science, Yamaguchi University
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YAMAGUCHI Ryoji
The United Graduate School of Veterinary Science, Yamaguchi University
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Yamaguchi Ryoji
The United Graduate School Of Veterinary Sci. Yamaguchi Univ.
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MAEDA Hiroshi
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.
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YAMAGUCHI Ryoji
The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
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