Studies on the Mode of Action of Fenvalerate Enantiomers. : III.Cuticular Penetration and Metabolism of Fenvalerate Enantiomers in the German Cockroach, Blattella germanica(L.)(Orthoptera:Blattellidae)
スポンサーリンク
概要
- 論文の詳細を見る
Insecticidal activity,cuticular penetration and metabolism of optical isomers of fenvalerate, R,S-S fenvalerate, (R,S) α-cyano-3-phenoxybenzyl (S)-2-(4-chlorophenyl)-isovalerate and R,S-R fenvalerate, (R,S) α-cyano-3-phenoxybenzyl (R)-2-(4-chlorophenyl)-isovalerate were studied using the German cockroach, Blatella germanica (L.). R,S-S fenvalerate was more than 3,800 times more potent than R,S-R fenvalerate. Cuticular penetration and metabolism experiments showed that [^<14>C] R,S-S fenvalerate penetrated more rapidly than [^<14>C] R,S-R fenvalerate. The patterns of in vivo metabolism of these two optical isomers were similar, showing little quantitative difference. These results showed that there was some difference in pharmacokinetic behavior between two optical isomers of fenvalerate, seemingly the result of a minor factor responsible for the difference in their bioactivities.
- 日本応用動物昆虫学会の論文
- 1991-02-25
著者
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MIYATA Tadashi
Laboratory of Applied Entomology and Nematology, Faculty of Agriculture, Nagoya University
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SAITO Tetsuo
Laboratory of Applied Entomology and Nematology, Faculty of Agriculture, Nagoya University
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Saito T
Shizuoka Agricultural Experiment Station Shizuoka Jpn
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Saito Tetsuo
Laboratory Of Applied Enlomology And Nematology Faculty Of Agriculture Nagoya University
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Miyata T
Nagoya Univ.
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Miyata Tadashi
Lab. Of Applied Entomology Graduate School Of Bio-agricultural Sciences Nagoya University
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Miyata Tadashi
Laboratory Of Applied Entomology And Nematology Factulty Of Agriculture Nagoya University
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MlNAMIYAMA Makoto
Laboratory of Applied Entomology and Nematology, Faculty of Agriculture, Nagoya University
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NAGATA Keiich
Laboratory of Applied Entomology and Nematology, Faculty of Agriculture, Nagoya University
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Nagata K
Nagoya Univ. Nagoya Jpn
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Nagata Keiichi
Brain Science Institute The Institute Of Physical And Chemical Research (riken):(present Address)dep
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Miyata T
Nagoya Univ. Nagoya Jpn
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Mlnamiyama Makoto
Laboratory Of Applied Entomology And Nematology Faculty Of Agriculture Nagoya University
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Saito Tetsuo
Laboraotory Of Applied Entomology And Nematology Faculty Of Agriculture Nagoya University
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