13C NMR Studies of Histidine Fermentation with a Corynebacterium glutamicum Mutant
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概要
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13C NMR spectroscopy was applied to studies on histidine biosynthesis in Corynebacterium glutamicum N-730, a histidine producing mutant. When it was cultured in a medium containing [1-13C]glucose as the carbon source, the 13C isotopomer was abundantly incorporated into C-6 (28 atom%) and C-1 (21%), and to a lesser extent into C-5 (7%) of the histidine accumulated. The high incorporation into C-6 was explained as being due to that most of the one-carbon unit for histidine biosynthesis is derived from serine. On the bases of this view and the 13C population value at C-6, .the contributions of the Embden-Meyerhof and hexose monophosphate pathways to the histidine production were calculated to be 56 and 44%, respectively. The significance of the label incorporation into C-1 and C-5 was discussed.
- 社団法人 日本農芸化学会の論文
著者
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SHIRAHATA Kunikatsu
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Araki Kazumi
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Kuga Tetsuro
Tokyo Res. Lab. Pharmaceutical Res. Lab. Technical Res. Lab. & Pharmaceutical Research And Devel
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ISHINO Shuichi
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Shirahata Kunikatsu
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Yamaguchi Kazuo
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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