Structural studies on fortimicins. III. The crystal and molecular structure of fortamine dihydrochloride.
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概要
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Fortamine dihydrochloride, C<SUB>8</SUB>H<SUB>18</SUB>N<SUB>2</SUB>O<SUB>4</SUB>·2HCl, is obtained by the hydrolysis of fortimicin B with hydrochloric acid. The space group is <I>C</I>2 with <I>a</I>=16.109(2), <I>b</I>=10.047(1), <I>c</I>=8.603(1) Å, β=108.69(1)°, and <I>Z</I>=4. The structure was solved by the heavy atom method, and least-squares refinement using 1564 reflexions led to the final <I>R</I> value of 0.030. The ring conformation of fortamine dihydrochloride is an inversed chair form of fortamine. The chair form is significantly compressed to relax the non-bonded interactions between axial substituents.
- 公益社団法人 日本化学会の論文
著者
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Shirahata Kunikatsu
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Ohashi Yuji
Laboratory Of Animal Science Kyoto Prefectural University
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Sasada Yoshio
Laboratory of Chemistry for Natural Products, Faculty of Science, Tokyo Institute of Technology
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Hirayama Noriaki
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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Hirayama Noriaki
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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