Complexes between nucleotide base and amino acid. II. Crystal structure of 5-bromocytosine: N-tosyl-L-glutamic acid.

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概要

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• The complex crystals of 5-bromocytosine and <I>N</I>-tosyl-L-glutamic acid were obtained from their aqueous solution. The space group is P1 with dimensions of <I>a</I>=10.843(1), <I>b</I>=11.690(2), <I>c</I>=10.879(2) Å, α=122.15(1), β=121.38(1), γ=69.93(1)°, and <I>Z</I>=2. The structure was solved by the heavy atom method and refined by a block-diagonal least-squares method. The undissociated γ-carboxyl group of glutamic acid is bound with O(2) and N(4) of 5-bromocytosine through hydrogen bonds. This interaction mode is different from those found in some cytosine : glycine complexes and cytidine : <I>N</I>-benzyloxycarbonyl-L-glutamic acid complex dihydrate in which the dissociated α-carboxyl group plays a role. This is the first example of interaction between cytosine and the acidic side group of amino acid.

• 公益社団法人 日本化学会の論文

著者

• Takenaka Akio

  Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology

• Sasada Yoshio

  Laboratory of Chemistry for Natural Products, Faculty of Science, Tokyo Institute of Technology

• Shimanouchi Hirotaka

  Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology

• Ohki Minoru

  Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology

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