Structural studies of fortimicins. IV. The crystal structure of fortamine sulfate trihydrate and the anion effect on fortamine conformation.

スポンサーリンク

概要

• 論文の詳細を見る

• The molecular and crystal structure of fortamine sulfate trihydrate, C<SUB>8</SUB>H<SUB>18</SUB>N<SUB>2</SUB>O<SUB>4</SUB>·H<SUB>2</SUB>SO<SUB>4</SUB>·3H<SUB>2</SUB>O, was determined by X-ray analysis. The space group is P2<SUB>1</SUB> with <I>a</I>=7.2516(9), <I>b</I>=11.193(1), <I>c</I>=9.022(1) Å, β=90.55(2)°, and <I>Z</I>=2. The structure was solved by direct methods, and least-squares refinement using 1679 reflexions led to the final <I>R</I> value of 0.063. The ring conformation of fortamine sulfate is a chair form which corresponds to a chair obtained by inversion of that in the dihydrochloride. This is an extraordinary example of the cyclohexane ring inversion caused by the anion exchange in the crystal. The ring conformation of fortamines in solution and in crystal are compared and discussed.

• 公益社団法人 日本化学会の論文

著者

• Shirahata Kunikatsu

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Ohashi Yuji

  Laboratory Of Animal Science Kyoto Prefectural University

• Sasada Yoshio

  Laboratory of Chemistry for Natural Products, Faculty of Science, Tokyo Institute of Technology

• Hirayama Noriaki

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

関連論文

• Solvent-dependent Stereochemical Anomaly in the Nucleophilic Addition of Ester-derived Enolate to Bicyclo[3,3,0]octan-2-one System of Diacetone Glucos-3-ulose
• Strain Gauge Force Transducer and Its Application in a Pig Model to Evaluate the Effect of Probiotic on Colonic Motility
• Lactobacillus casei Strain Shirota-fermented Milk Stimulates Indigenous Lactobacilli in the Pig Intestine
• K-254-I(Genistein), a New Inhibitor of Ca^ and Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase from Streptosporangium vulgare(Biological Chemistry)
• Stimulation of Indigenous Lactobacilli by Fermented Milk Prepared with Probiotic Bacterium, Lactobacillus delbrueckii subsp. bulgaricus Strain 2038, in the Pigs
• Stimulation of Cytokine Gene Expression in a Murine Macrophage Cell Line by Lactic Acid Bacteria Isolated from Bhutanese Dried Yak Cheese
• The Effect of Lactobacillus casei Strain Shirota on the Cecal Fermentation Pattern Depends on the Individual Cecal Microflora in Pigs
• K-251 Compounds, Inhibitors of Ca^ and Calmodulin-dependent Cyclic Nucleotide Phosphodiesterase from Streptoverticillium album(Biological Chemistry)
• PA157 STRUCTURE DETERMINATION OF THE NOVEL ANTHRAQUINONE ANTIBIOTICS DC92-B AND DC92-D
• Influences of Prebio Support^ (Mixture of Fermented Products of Lactobacillus gasseri OLL2716 and Propionibacterium freudenreichii ET-3) on the Composition and Metabolic Activity of Fecal Microbiota in Calves
• Acetogenic Bacteria Mainly Contribute to the Disposal of Hydrogen in the Colon of Healthy Japanese
• Influences of Lactobacillus and Cellobiose on the Composition and Metabolic Activity of Fecal Microbiota in Dogs given Boiled Chicken Head and Cow Milk
• Analysis of Acetogenic Bacteria in Human Feces with Formyltetrahydrofolate Synthetase Sequences
• Isolation of Albomitomycins from Solutions of 7-Amino Substituted Mitomycins;Mitomycin C and KW-2149
• SYNTHESIS OF MITOMYCIN DERIVATIVES WITH DISULFIDE AT THE 7-N SIDE CHAIN (3). SYNTHESIS OF KW2149 AND STRUCTURE-ACTIVITY RELATIONSHIPS AMONG MITOMYCIN DERIVATIVES WITH DISULFIDE AT THE 7-N SIDE CHAIN
• ^C NMR Studies of Lysine Fermentation with a Corynebacterium glutamicum Mutant(Microbiology & Fermentation Industry)
• The Composition of Intestinal Bacteria Affects the Level of Luminal IgA
• Strain Gauge Force Transducer and Its Application in a Pig Model to Evaluate the Effect of Probiotic on Colonic Motility
• Involvement of meso-α, ε-Diaminopimelate D-Dehydrogenase in Lysine Biosynthesis in Corynebacterium glutamicum
• Crystal and molecular structure of (ethyl methacrylate)-bis(triphenylphosphine)nickel(0).
• Complexes between nucleotide base and amino acid. II. Crystal structure of 5-bromocytosine: N-tosyl-L-glutamic acid.
• Crystal and molecular structures of octaethylporphinium(monocation) triiodide and its benzene hemisolvate.
• The crystal and molecular structure of N-carboxy-.GAMMA.-benzyl-L-glutamate anhydride.
• Crystal and molecular structure of methyl D-tetronitroside.
• Structural studies of fortimicins. IV. The crystal structure of fortamine sulfate trihydrate and the anion effect on fortamine conformation.
• Conformation of condensed polycyclic aromatic hydrocarbons. II. The molecular and crystal structure of violanthrene B (dibenzo(a, rst)naphtho(8,1,2-cde)pentaphene).
• Crystal Structure of p-Bromobenzylideneacetone
• Crystal structure of adenine-1-(2-carboxyethyl)uracil (1:1) complex. A model for interactions of amino acid side chains with nucleic acid base pair.
• Crystal structures of mixed ligand copper(II) complexes containing L-amino acids. I. L-asparaginato-L-histidinatocopper(II) and its hydrate.
• Structural studies of asymmetric hydrogenation. IV. The crystal structures of [(R)-1-cyanoethyl][(S)(-)-.ALPHA.-methylbenzylamine]bis(dimethylglyoximato)cobalt(III) at 293 K and 173 K.
• Crystal and molecular structure of antibiotic gilvocarcin M.
• A model for interactions of amino acid side chains with Watson-Crick base pair of guanine and cytosine. Crystal structures of 9-(2-carboxyethyl)guanine and its crystalline complex with 1-methylcytosine.
• Preparations and properties of optically active (alkyl)bis(dimethylglyoximato)cobalt(III) complexes.
• The crystal structure of 13H-dibenz(a,de)anthracen-13-one.
• The Crystal Structure of Pyrazinic Acid
• Conformation of condensed polycyclic aromatic hydrocarbons. I. The molecular and crystal structure of anthra(2,1,9,8-hijkl)-benzo(de)naphtho(2,1,8,7-stuv)pentacene.
• 13C NMR Studies of Histidine Fermentation with a Corynebacterium glutamicum Mutant
• The crystal and molecular structure of echinosporin.
• Structure of Fusariocin C, A Cytotoxic Metabolite from Fusarium Moniliforme
• The Crystal and Molecular Structure of 2,5-Distyrylpyrazine
• The Crystal and Molecular Structure of Butein Monohydrate, Isolated from Dahlia variabilis
• The Crystal and Molecular Structure of Miyaconitine Hydrobromide Dihydrate
• The crystal structure of a stable benzocyclobutene. II. 2,7-Di-t-butyl-10,10,11,11-tetracyano-4,5,9,12-tetraphenyltetracyclo[6.4.0.03,6.09,12]dodeca-1(8),2,4,6-tetraene.
• The Crystal and Molecular Structure of 4,10b-Methano-8H-benzo[ab]cyclodecen-8-one
• Structural studies of asymmetric hydrogenation. II. The crystal structure of methyl(R(+)-.ALPHA.-methylbenzylamine)bis(dimethylglyoximato)cobalt(III) benzene solvate.
• Structural studies on fortimicins. III. The crystal and molecular structure of fortamine dihydrochloride.

もっと見る 閉じる

スポンサーリンク