ANTI-INFLAMMATORY PROPERTIES OF A NEWLY SYNTHETIZED COMPOUND, 6-CHLORO-4-OXYIMINO-1-PHENYL-1, 2, 3, 4-TETRAHYDROQUINOLINE (M-7074)
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概要
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Anti-inflammatory properties of a newly synthetized compound, 6-chloro-4-oxyimino-1-phenyl-1, 2, 3, 4-tetrahydroquinoline (M-7074), have been investigated. Anti-edema activities of M-7074 were more potent than those of phenylbutazone in carrageenin, bradykinin and mustard edema tests in rats. M-7074 showed an inhibitory effect on adjuvant arthritis, especially on the secondary inflammatory lesions in rats. Inhibitory effect of M-7074 on cotton-pellet granuloma formation was all but equal to that of phenylbutazone in rats. M-7074 also showed inhibitory effects on ultraviolet erythema in guinea-pigs and increased vascular permeability in mice, moderate analgesic activity in rats and mice, and antipyretic activity in rats. Furthermore, inhibitory effects of M-7074 on prostaglandin biosynthesis in guinea-pig lung homogenate and arachidonic acid-induced aggregation of rabbit platelets were fairly equal to those of indomethacin. However, M-7074 showed no effect on humoral nor cellular immunity in mice. M-7074 possessed no ulcerogenic activity in rats and mice, and LD50 value of M-7074 was 8.01 g/kg, p.o. in mice. These data indicate that M-7074 is a novel anti-inflammatory agent with large margin of safety.
- 社団法人 日本薬理学会の論文
著者
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YAMAGUCHI Kazuo
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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OHNISHI Haruo
Tokyo Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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KOSUZUME Hiroshi
Tokyo Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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OHKURA Masatsugu
Tokyo Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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SATOH Masami
Tokyo Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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UOHAMA Misao
Tokyo Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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TOYONAKA Yoko
Tokyo Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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SUZUKI Yasuo
Tokyo Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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Yamaguchi Kazuo
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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YAMAGUCHI Kazuo
Tokyo Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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