Daedalin A, a Metabolite of Daedalea dickinsii, Inhibits Melanin Synthesis in an in Vitro Human Skin Model
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概要
- 論文の詳細を見る
The culture broth of Daedalea dickinsii was found to predominantly contain the tyrosinase inhibitor, (2R)-6-hydroxy-2-hydroxymethyl-2-methyl-2H-chromene, daedalin A (1). Ongoing research into bioactive metabolites resulted in the identification of two new 2H-chromenes, 6-hydroxy-5,7-dimethoxy-2,2-dimethyl-2H-chromene (3) and 6-hydroxy-2-hydroxymethyl-5-methoxy-2-methyl-2H-chromene (4), together with 6-hydroxy-2,2-dimethyl-2H-chromene (2). Comparative studies of isolated compounds 1–4 and related compounds (±)-1 and 1a–1c showed 1 to have the strongest tyrosinase inhibitory activity. These results suggest that the hydroxyl groups at positions 6 and 9 of 1 were important for the potent activity. A Lineweaver-Burk plot for a kinetic analysis indicates that 1 competed with L-tyrosine for tyrosinase. Compound 1 also suppressed melanogenesis in a human skin model (up to 49% at 2.8 μmol/tissue application) without affecting the cell viability. Compounds 1, 1b and 1c also showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity comparable to that of α-tocopherol.
- 社団法人 日本農芸化学会の論文
- 2009-03-23
著者
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HIROTA Mitsuru
Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University
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Mori H
Division Of Pathology National Institute Of Health Sciences
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Hirose Masao
国立医薬品食品衛生研究所 病理
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Hirose M
Division Of Pathology National Institute Of Health Sciences:food Safety Commission
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Hirose Masao
国立医薬品食品衛生研究所 病理部
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Hirose Masao
名古屋市立大学 医学研究科実験病態病理学
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Mori Hideki
岐阜薬科大学 生物薬学研究所
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Makita Hiroki
岐阜大学 第1病理
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Hirose Masao
Division Of Pathology National Institute Of Health Sciences
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Hirose Masao
Div. Pathol. Natl. Inst. Htlh. Sci.
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Hirota M
Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University
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Hirota Mitsuru
Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University
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Hosono M
Aburahi Laboratories Shionogi Research Laboratories Shionogi Co Ltd.
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Makabe Hidefumi
Science of Functional Foods, Graduate School of Agriculture, Shinshu University
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Makabe H
Shinshu Univ. Nagano Jpn
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Mori Hideki
College Of Engineering Graduate School Of Osaka Prefecture University
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HIRAMATSU KENJI
Department of Anesthesiology, Kinki University School of Medicine
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Hiramatsu Kenji
Department Of Anesthesiology Kinki University School Of Medicine
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Mori Hideki
First Department Of Pathology Gifu University School Of Medicine
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MORIMURA Keiji
Interdisciplinary Graduate School of Science and Technology, Shinshu University
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YAMAZAKI Chihiro
Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University
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HATTORI Yasunao
Interdisciplinary Graduate School of Science and Technology, Shinshu University
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Hiramatsu Kenji
Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University
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Yamazaki Chihiro
Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University
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