Hepatic Injury and Gluconeogenesis After Subcutaneous Injection of Monochloroacetic Acid in Rats
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概要
- 論文の詳細を見る
Objective: Monochloroacetic acid (MCA) is corrosive to skin, and causes not only chemical injury but also fatal systemic poisoning. Little is known about the cause of death. We studied the acute toxicity of MCA before clinical symptoms appeared in fasting rats. Methods: Blood samples were analyzed 2 h after subcutaneous MCA injection (LD_<90>: 162 mg/ml kg body weight). Control rats were injected with saline. Results: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were about 1.5-fold higher than in the controls, and mitochondrial AST (mAST) was 2-fold higher. Blood urea nitrogen and creatinine were significantly increased, while serum glucose was significantly decreased in the treated group. Lactate was 6-fold higher and pyruvate was 13-fold higher than in the controls. Conclusions: MCA caused injury to the liver and kidneys but these injuries were slight. However, the larger increase in mAST indicated that hepatocellular mitochondria were selectively targeted. Hepato-cellular mitochondrial injury decreased gluconeogenesis and caused hypoglycemia and extremely high levels of lactate and pyruvate. Hypoglycemia and lactic acidosis were insidious before the critical symptoms appeared and this combination accelerated to death, affecting other organs such as the heart and brain. Nosotropic therapy of these abnormalities up to the appearance of symptoms may help to establish an early therapy for skin exposure to MCA.
- 日本衛生学会の論文
著者
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KONO Koichi
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University
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Kono Koichi
大阪医科大学 衛生学･公衆衛生学
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Usuda Kan
Department Of Hygiene And Public Health Osaka Medical College
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Usuda Kan
Department Of Hygiene & Public Health Osaka Medical College
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Dote Tomotaro
Dep. Of Hygiene And Public Health Osaka Medical Coll.
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Dote Tomotaro
Department Of Hygiene And Public Health Osaka Medical College
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SHIMIZU Hiroyasu
Department of Electronic Engineering, Faculty of Engineering, Nagoya University
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Dote Tomotaro
Department Of Hygiene And Public Health I・ii Osaka Medical College
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Kono Koichi
Department Of Hygiene And Public Health I・ii Osaka Medical College
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Kono Koichi
こうの こういち
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Toshina Yumi
Department Of Hygiene And Public Health Division Of Preventive And Social Medicine Osaka Medical Col
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TOMINAGA Mika
Department of Hygiene and Public Health, Osaka Medical College
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Usuda Kan
Division Of Preventive And Social Medicine Department Of Hygiene And Public Health Osaka Medical Col
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Shimizu Hiroyasu
Division Of Preventive And Social Medicine Department Of Hygiene And Public Health Osaka Medical Col
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Shimizu Hiroyasu
Department Of Electrical Engineering Faculty Of Engineering Gifu University:the Institute Of Optics
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Tominaga Mika
Department Of Hygiene And Public Health Osaka Medical College
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Usuda Kan
Osaka Medical Coll. Osaka Jpn
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Usuda Kan
Department Of Hygiene And Public Health Division Of Preventive And Social Medicine Osaka Medical Col
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