Afterloading Increases the Left Ventricular End-Systolic Force-Length Relation Slope in Dogs.
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概要
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We evaluated the effects of pressure loading produced by gradual aortic occlusion on left ventricular (LV) myocardial contractility by assessing changes in the slope of the LV end-systolic force-diameter (Fes-Des) relation. Eleven adult mongrel dogs were prepared with ultrasonic crystals for measuring LV diameter and a micromanometer for measuring LV pressure. Preload was decreased by vena caval occlusion (VCO), and afterload was increased by aortic occlusion (AOO). The slopes (Ec) and extrapolated diameter intercepts (Do) of the LV Fes-Des relation were determined for each dog from the end-systolic data obtained during VCO and AOO. During VCO and also AOO, the heart rate showed little change (134±18 vs. 134±16bpm in VCO, 135±16 vs. 132±17bpm in AOO). The values of Ec and Do during VCO were 62.8±15.6g/cm and 1.20±0.36cm, respectively, while during AOO the respective values were 122.6±18.6g/cm and 1.66±0.38cm. Ec and Do were both significantly increased during AOO in comparison with VCO (p<0.001). These results suggest that gradual aortic occlusion increases LV myocardial contractility in anesthetized, open-chest dogs under autonomic blockade. This phenomenon might be related to length-dependent calcium activation.
- International Heart Journal刊行会の論文
著者
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Takeda Kouichi
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Yagi Shigeru
Department Of Medicine And Laboratory Of Medical Science
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Shimizu Takahiko
Department Of Aging Control Medicine Juntendo University Graduate School Of Medicine
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Nakamura Yasuyuki
Department Of Biological Science And Technology Science University Of Tokyo
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SHIMIZU Takahiko
Department of Medicine, Division of Hypertension and Cardiorenal Diseases, Dokkyo University School of Medicine
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NAKAMURA Yasuyuki
Department of Medicine, Division of Hypertension and Cardiorenal Diseases, Dokkyo University School of Medicine
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KADOTA Ryutaro
Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School of Medicine
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TAKEDA Kouichi
Department of Medicine, Division of Hypertension and Cardiorenal Diseases, Dokkyo University School of Medicine
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