Association between Serum Adiponectin Levels and Arteriolosclerosis in IgA Nephropathy Patients
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概要
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Objective: Adiponectin has attracted great attention because of its anti-atherogenic properties; however, to date the relationship between serum adiponectin and arteriolosclerosis has not been reported. In our study, we aimed to examine whether or not serum adiponectin levels are associated with arteriolosclerosis in patients with IgA nephropathy which is the most common form of chronic glomerulonephritis. Materials and Methods: We enrolled 35 patients aged 35.0±14.6, who underwent renal biopsy from August 2004 to February 2006 in our hospital, and were confirmed to have IgA nephropathy. We examined serum adiponectin, high-sensitive C-reactive protein, total cholesterol and triglyceride level, urinary protein excretion, body mass index (BMI), and the presence of arteriolosclerosis in the renal specimens. Since the serum adiponectin level is strongly affected by renal function, we classified the patients by creatinine clearance. Results: Multiple regression analysis showed the associations of adiponectin with creatinine clearance (p<0.001), BMI (p<0.001), serum triglyceride (p=0.001) and urinary protein excretion (p=0.001). We observed a positive relation of adiponectin with urinary protein excretion and an inverse relation of adiponectin with creatinine clearance, serum triglyceride, and BMI. We could not detect any relation between the presence of arteriolosclerosis and adeponectin in the IgA nephropathy patients as a whole; however, in patients whose creatinine clearance was 90-120 ml/min/1.73 m2, the serum adiponectin level of patients with arteriolosclerosis was lower than in those without arteriolosclerosis (p=0.025). Conclusion: The serum level of adiponectin was related to arteriolosclerosis in IgA nephropathy patients whose renal function was almost normal. Adiponectin may prevent renal arteriolosclerosis.
- 社団法人 日本内科学会の論文
著者
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Uchida Keiko
Department of Medicine, Kidney Center, Tokyo Womens Medical University
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Yumura Wako
Department of Nephrology, Jichi Medical University
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Nitta Kosaku
Department of Medicine, Kidney Center, Tokyo Womens Medical University
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Uchida Keiko
Department Of Medicine Kidney Center Tokyo Women's Medical University
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Yumura W
東京女子医科大学附属腎臓病総合医療センター 腎臓内科
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Yumura Wako
Department Of Medicine Kidney Center Tokyo Women's Medical University
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Otsubo Shigeru
Department Of Electrical Engineering Ishikawa National College Of Tecchnology Tsubata
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TAKAHASHI Masaki
Department of Medicine, Kidney Center, Tokyo Women's Medical University
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Nitta Kosaku
Department Iv Of Internal Medicine Tokyo Women's Medical University
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Takahashi Masaki
Department Of Analytical Biochemistry Meiji Pharmaceutical University
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Otsubo Shigeru
Department of Blood Purification, Sangenjaya Hospital, Japan
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TAKAHASHI Masaki
Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University
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