Aortic Arch Calcification and Arterial Stiffness are Independent Factors for Diastolic Left Ventricular Dysfunction in Chronic Hemodialysis Patients
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概要
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Background Because cardiovascular disease is the major cause of death in dialysis patients, the correlation between diastolic left ventricular (LV) dysfunction and arterial sclerosis, including thoracic aortic calcification, was studied in chronic hemodialysis (HD) patients. Methods and Results The enrolled study subjects were 142 (73 men, 69 women) maintenance HD patients. Aortic arch calcification volume (AoACV) was measured by MDCT scan, arterial stiffness was estimated by brachial-ankle pulse wave velocity (PWV) and diastolic LV function was estimated as E/E' by tissue Doppler imaging with cardiac ultrasonography. E/E' correlated significantly with systolic blood pressure (r=0.29, p=0.037), age (r=0.19, p=0.02), LV mass index (r=0.18, p=0.036), dialysis vintage (r=0.19, p=0.037), AoACV (r=0.37, p<0.0001) and PWV (r=0.33, p=0.0002). Multiple regression analysis indicated that AoACV (β=0.26, p=0.005) and PWV (β=0.22, p=0.03) were independent determinants of E/E'. Conclusion Diastolic LV dysfunction may be induced by increased vascular calcification and reduced arterial stiffness in chronic HD patients.
- 社団法人日本循環器学会の論文
- 2008-10-20
著者
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Nitta Kosaku
Department of Medicine, Kidney Center, Tokyo Womens Medical University
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Kamatani Naoyuki
Laboratory For Statistical Analysis Center For Genomic Medicine Riken
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Ohishi Tetsuya
Laboratory Of Molecular Medicine Human Genome Center Institute Of Medical Science The University Of
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Ogawa Tetsuya
Department Of Medicine Kidney Center Tokyo Women's Medical University
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Nitta K
Department Of Medicine Kidney Center Tokyo Women's Medical University
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Nitta Kosaku
Department Of Medicine Kidney Center Tokyo Women's Medical University
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Nitta Kosaku
大阪大学 医学系研究科老年腎臓内科学
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MATSUDA Nami
Department of Medicine, Kidney Center, Tokyo Women's Medical University
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FUJIU Ayuko
Department of Medicine, Kidney Center, Tokyo Women's Medical University
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Ando Yoshitaka
Hidaka Hospital
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Kamatani Naoyuki
理化学研究所ゲノム医科学研究センター 循環器疾患研究チーム
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Nitta Kosaku
Department Of Internal Medicine Kidney Center Tokyo Women's Medical University
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Fujiu Ayuko
Department Of Medicine Kidney Center Tokyo Women's Medical University
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Natori Kyoko
Department Of Medicine Kidney Center Tokyo Women's Medical College
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Matsuda Nami
Department Of Medicine Kidney Center Tokyo Women's Medical University
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Nakai K
Department Of Medicine Kidney Center Tokyo Women's Medical University
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Ogawa Tetsuya
Department Of Applied Science For Electronics And Materials Kyushu University
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Nitta Kosaku
Department Iv Of Internal Medicine Tokyo Women's Medical University
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Nitta Kosaku
Dep. Of Medicine Kidney Center Tokyo Women's Medical Univ.
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