Plasma Renin Activity Determined by Two Different Methods in Spontaneously Hypertensive Rats
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概要
- 論文の詳細を見る
As a discrepancy exists between two reports from our laboratory on plasma renin activity (PRA) in spontaneously hypertensive rats (SHR), we undertook to examine the reasons for this discrepancy. PRA in SHR at 15 weeks of age was determined by two different methods, utilizing the procedures of Boucher et al or of Haber et al. For normotensive controls. Donryu (DON) and Wistar-Kyoto (WKY) rats were used. By Bouchers method, PRA in SHR was significantly lower than in DON, but did not differ from WKY. By Habers method, PRA in SHR did not significantly differ from DON or WKY. However, the value in DON was significantly higher than in WKY. The present study basically confirmed our previous results, concluding that PRA in SHR at 15 weeks of age is within the normal range. A previous suggestion that PRA in SHR is suppressed as a result of blood pressure elevation must be revised, because it was derived from results considering only the DON strain as the control.
- International Heart Journal刊行会の論文
著者
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KURIYAMA Satoru
Department of Internal Medicine, Saiseikai Central Hospital, Second Department of Internal Medicine,
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KAWASHIMA Koichiro
Department of Mechanical Engineering, Nagoya Institute of Technology
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SOKABE HIROFUMI
Department of Pharmacology, Jichi Medical School
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Kuriyama Satoru
Department Of Internal Medicine Saiseikai Central Hospital Second Department Of Internal Medicine Ji
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Sokabe Hirofumi
Department Of Parmacology Toho University Shool Of Medicine
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Kawashima Koichiro
Department Of General Education Nagoya University
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KAWASHIMA KOICHIRO
Department of Pharmacology, Jichi Medical School
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KURIYAMA Satoru
Department of Pharmacology, Jichi Medical School
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SOKABE Hirofumi
Departine rt of Pharmacology, Jichi Medical School
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KAWASHIMA Koichiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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- Preface
- Expression of Choline Acetyltransferase mRNA and Protein in T-Lymphocytes
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- THE RATIO OF CARDIAC TO VASCULAR β-RECEPTOR BLOCKADE OF ATENOLOL AND PROPRANOLOL IN SPONTANEOUSLY HYPERTENSIVE RATS IN VIVO
- The Spontaneously Hypertensive Rat (8) : Proceedings of VIII Annual Scientific Meeting of the Council for the Spontaneously Hypertensive Rat October 8, 1972, Nagasaki
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