Benefits and Demerits of Antihypertensive Therapy by High-Dose Calcium Channel Blocker in Severely Hypertensive Rats.
スポンサーリンク
概要
- 論文の詳細を見る
This study examined the protective effects of a calcium channel blocker, nisoldipine (NSL), against organ damage secondary to severe hypertension. Severe hypertension was induced in male 7-week-old spontaneously hypertensive rats (n=21) by heminephrectomy and substitution of 1% NaCl solution for drinking water. They were fed a chow containing 0%, 0.03% (low dose) or 0.1% (high dose) NSL for 12 weeks. The systolic blood pressures after 12 weeks were 228mmHg in the control group, 201 in the low dose NSL group and 188 in the high dose NSL group. Body weight gain was blunted in the high dose NSL group (at 12 weeks: control 289g; low dose NSL 286; high dose NSL 263, p<0.04). Although a further reduction in cardiac weight was seen in the high dose NSL rate (low NSL -5.2%, p<0.05; high NSL -9%, p<0.01), reductions in aortic thickness did not differ between the 2 doses (low NSL -18%, p<0.001; high NSL -17%, p<0.001). Moreover, dose-dependent effects of NSL treatment were absent for such endpoints as plasma creatinine (low NSL -15%, p<0.04; high NSL -17%, p<0.05), glomerular filtration rate (low NSL +21 %, p<0.05; high NSL +20%, p<0.03) and urinary protein excretion (low NSL -22%, p<0.05; high NSL -29%, p<0.02). Thus, a high dose calcium channel blocker hampered growth and did not further improve vascular wall thickening or renal injury in severely hypertensive rats. Therefore, in treating hypertension, combination of other antihypertensive drugs may be recommended rather than using high doses of calcium channel blockers.
- International Heart Journal刊行会の論文
著者
-
Tsukada Hiroki
Department Of Medicine Ii Niigata University Graduate School Of Medical And Dental Sciences
-
Ogawa Yoshiichi
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
-
Yagi Shigeru
Department Of Medicine And Laboratory Of Medical Science
-
Ishimitsu Toshihiko
Department of Cardiology and Nephrology, Dokkyo Medical University School of Medicine
-
ISHIMITSU Toshihiko
Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School of Medicine
-
TSUKADA Hiroki
Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School of Medicine
関連論文
- Effects of Nicorandil on Cardiovascular Events in Patients With Coronary Artery Disease in The Japanese Coronary Artery Disease (JCAD) Study
- Left ventricular systolic and diastolic function along the long axis before and after antihypertensive treatment in patients with essential hypertension
- Urinary excretion of liver fatty acid-binding protein in health-check participants
- Comparison between Cilnidipine and Nisoldipine with Respect to Effects on Blood Pressure and Heart Rate in Hypertensive Patients
- Angiotensin-II receptor antagonist combined with calcium channel blocker or diuretic for essential hypertension
- Combination Therapy With Telmisartan and Spironolactone Alleviates L-NAME Exacerbated Nephrosclerosis With an Increase in PPAR-γ and Decrease in TGF-β1
- Long-Term Efficacy of Combination Therapy With Losartan and Low-Dose Hydrochlorothiazide in Patients With Uncontrolled Hypertension
- Relationship Between Markers of Inflammation and Brachial-Ankle Pulse Wave Velocity in Japanese Men
- Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction
- Effectiveness of Oseltamivir Treatment among Children with Influenza A or B Virus Infections during Four Successive Winters in Niigata City, Japan
- Year-Long Antihypertensive Therapy With Candesartan Completely Prevents Development of Cardiovascular Organ Injuries in Spontaneously Hypertensive Rats
- -124-THE CHANGE OF MYOCARDIAL OXYGEN TENSION IN ACUTE MYOCARDIAL ISCHEMIA AND REPERFUSION : EFFECT OF DILTIAZEM ON SUBENDOCARDIAL OXYGEN TENSION : Cardiovascular Drugs : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAP
- 2 Cariorenal Association in Prognosis of Chronic Cardiovascular Disease and Renal Disease : Significance of Neurohumoral Activation(Cardiorenal Syndrome and Hypertensive Heart Diseases, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
- Positive association of CYP11B2 gene polymorphism with genetic predisposition to essential hypertension
- Incidence of cardiovascular diseases and angiotensin-converting enzyme gene polymorphism in chronic hemodialysis patients
- Relations of Blood Pressure Values to the Risks of Death and Cardiovascular Events in Chronic Hemodialysis Patients(Hypertension, Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- THE ALTERATION OF MONOPHASIC ACTION POTENTIAL (MAP) AND VENTRICULAR GRADIENT (VG) IN MYOCARDIAL ISCHEMIA
- Effects of Valsartan on the Progression of Chronic Renal Insufficiency in Patients with Nondiabetic Renal Diseases
- 2-hour Postchallenge Blood Glucose was More Closely Related to Brachial-ankle Pulse Wave Velocity than Fasting Blood Glucose in Japanese Men (Diabetes/Obesity 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Present Status of Blood Pressure Control in a Group of Hypertensive Patients Followed-up in a Cardiovascular Outpatient Clinic
- Responses of Natriuretic Peptides to Acute and Chronic Salt Loading in Normotensive and Hypertensive Subjects
- Effect of Candesartan on Left Ventricular Systolic Function along the Long Axis in Patients with Essential Hypertension
- Predictive Significance of Blood Pressure Values for the Incidence of Cardiovascular Events in Chronic Hemodialysis Patients
- PE-105 Influence of Anemia and Inflammation on the Risks of Death and Cardiovascular Events in Chronic Hemodialysis Patients(Kidney/Renal circulation(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-161 Smoking Habits Deteriorate Arterial Compliance and Increase Central Blood Pressure despite a Similar Effect on Brachial Blood Pressure(Smoking(H),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Lower Birth Weight Is Associated with Higher Resting Heart Rate during Boyhood
- Efonidipine Reduces Proteinuria and Plasma Aldosterone in Patients with Chronic Glomerulonephritis
- Efonidipine, a Calcium Channel Blocker, Alleviates Renal Injury Induced by Nitric Oxide Synthase Inhibition in Spontaneously Hypertensive Rats
- Valsartan improves L-NAME-exacerbated cardiac fibrosis with TGF-β inhibition and apoptosis induction in spontaneously hypertensive rats
- Calcium Antagonist Inhibits Glomerular Cell Apoptosis and Injuries of L-NAME Exacerbated Nephrosclerosis in SHR
- evidence-based practice guideline for the treatment of chronic kidney disease
- Effects of Imidapril on Left Ventricular Mass in Chronic Hemodialysis Patients
- Protective Effects of an Angiotensin II Receptor Blocker and a Long-Acting Calcium Channel Blocker against Cardiovascular Organ Injuries in Hypertensive Patients
- -103-AUGMENTATION OF DIGITALIS ON BEZOLDJARISCH REFLEX
- NEW INTERPRETATION OF SYSTOLIC TIME INTERVALS FROM ACTIVE CROSS-BRIDGE MODEL
- EFFECT OF α_1-ADRENOCEPTOR BLOCKADE ON THE LEFT VENTRICULAR FORCE-LENGTH RELATIONSHIP IN DOGS
- -0109- CORONARY FLOW RESERVE DURING THE REGRESSION AND DEVELOPMENT OF CARDIAC HYPERTROPHY IN RENOVASCULAR HYPERTENSIVE RATS:COMPARISON OF CALCIUM ANTAGONIST AND VASODILATOR AGENT(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATIO
- Relation of CYP11B2 Gene Polymorphism to the Incidence of Cardiovascular Diseases in Chronic Hemodialysis Patients
- PE-466 Clinical Usefulness of a Newly Developed Instrument for Non-invasive Monitoring of Beat-by-beat Cardiovascular Hemodynamic Parameters(Cardiac Function, Basic/Clinical 3 (M) : PE79)(Poster Session (English))
- OJ-248 Losartan Reduced Massive Proteinuria in Chronic Renal Disease Patients with Lower Renal Tissue TGF-beta1 mRNA Levels(Hypertension, Clinical 5 (H) : OJ29)(Oral Presentation (Japanese))
- A Contractility Index Independent of Myocardial Length : CLINICAL EVALUATION OF CARDIAC PERFORMANCE
- STUDIES ON THE VECTORCARDIOGRAM USING A LEAD-AXIS ROTATION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION : Electrocardiography : I : 48 Annual Scientific Meeting, Japanese Circulation Society
- STUDIES ON THE HIGH-FREQUENCY COMPONENTS IN THE QRS COMPLEX USING A FAST FOURIER TRANSFORM IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION : Electrocardiography : 46th Annual Scientific Meeting, Japanese Circulation Society
- MECHANISM OF EARLY APPEARANCE OF AORTIC SECOND HEART SOUND IN UREMIC PATIENTS : Kidney・Hypertension : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- 0888 EFFECTS OF ANTIHYPERTENSIVE DRUGS ON NITRIC OXIDE SYNTHASE AND MICROVASCULAR REMODELING IN DEOXYCORTICOSTERONE ACETATE-SALT HYPERTENSIVE RATS
- -466- PHARMACOKINETICS OF MEXILETINE IN HEMODIALYSIS PATIENTS
- An Autopsy Case of Disseminated Cryptococcosis Manifesting as Acute Diarrhea in a Patient with Primary Biliary Cirrhosis
- Valsartan reduced cardiac fibrosis by caspase-3 activation and TGF-β reduction in L-NAME/SHR in vivo
- -0992-THE RELATION BETWEEN INFARCT SIZE, CARDIAC FUNCTION AND THE INITIAL POTENTIAL OF THE SIGNAL-AVERAGED QRS COMPLEX IN PATIENTS WITH MYOCARDIAL INFARCTION : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- SPATIAL ORIENTATION OF THE VECTORCARDIOGRAM IN PATIENTS WITH MYOCARDIAL INFARCTION
- Cardioprotective Effect of Apelin-13 on Cardiac Performance and Remodeling in End-Stage Heart Failure
- Effects of Efonidipine, an L- and T-type Calcium Channel Blocker, on the Renin-Angiotensin-Aldosterone System in Chronic Hemodialysis Patients
- Retrospective investigation of the clinical effects of tazobactam/piperacillin and sulbactam/ampicillin on aspiration pneumonia caused by Klebsiella pneumoniae
- Renal Lesions of Streptozotocin-Induced Diabetes Mellitus in Spontaneously Hypertensive Rats
- Effects of Microsphere Suspension Agents of Systemic Hemodynamics in Rats. Comparison of Nonradioactive Colored and Radioactive Microspheres.:Comparison of Nonradioactive Colored and Radioactive Microspheres
- Angiotensin-Converting Enzyme Gene Polymorphism and Cardiovascular Endocrine System in Coronary Angiography Patients.
- Long-Term Evaluation of Combined Antihypertensive Therapy with Lisinopril and a Thiazide Diuretic in Patients with Essential Hypertension.
- Benefits and Demerits of Antihypertensive Therapy by High-Dose Calcium Channel Blocker in Severely Hypertensive Rats.
- Cross-bridge cycling energy of cardiac muscle estimated from an active cross-bridge model.
- Afterloading Increases the Left Ventricular End-Systolic Force-Length Relation Slope in Dogs.