Year-Long Antihypertensive Therapy With Candesartan Completely Prevents Development of Cardiovascular Organ Injuries in Spontaneously Hypertensive Rats
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概要
- 論文の詳細を見る
Most previous studies have examined the effects of antihypertensive drugs in hypertensive animals for only a few months, and little information has been provided as to the protective effects of lifetime antihypertensive medication against cardiovascular organ injury. In this study, spontaneously hypertensive rats (SHR) were treated for 1 year with an angiotensin-II receptor antagonist (ARB) and the development of hypertensive organ injury was evaluated. Male 15-week-old SHR (n = 9) were given 25 mg/L candesartan (CS) in their drinking water for 1 year. Twelve SHR and 9 normotensive Wistar-Kyoto rats (WKY) were given normal tap water. Tail-cuff blood pressure was almost normalized by CS throughout 1 year (at 12-months: WKY 132 ± 3, SHR 229 ± 3, CS 137 ± 4 mmHg). After 1 year, cardiac ventricular weight (SHR +33%, CS -2% versus WKY) and aortic thickness (SHR +34%, CS +4% versus WKY) in the CS-treated SHR rats were not different than those of WKY. Echocardiographic midwall fractional shortening (SHR -18%, CS -1% versus WKY) and left ventricular hydroxyproline content (SHR +47%, CS +11% versus WKY) were also improved by CS to the WKY level. With respect to kidney function, GFR (SHR -24%, CS +9% versus WKY) was preserved, proteinuria (SHR +312%, CS +12% versus WKY) was reduced, and the histological glomerular injury rate (SHR +186%, CS +6% versus WKY) was reduced by CS. These results suggest that long-term antihypertensive therapy with CS can completely prevent hypertensive cardiovascular and renal injuries in SHR.
著者
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MATSUOKA Hiroaki
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu
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Ishimitsu Toshihiko
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
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Honda Takeaki
Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine
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ONO Hidehiko
Department of Cardiovascular Medicine, Hypertension and Cardiorenal Medicine, Dokkyo University Scho
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Takahashi Toshiaki
Department of Hypertension and Cardiorenal Disease, Dokkyo Medical University
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Ohno Eri
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University
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Furukata Satoshi
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University
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Sudo Yasuyo
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University
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Nakano Nobuyuki
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University
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Sudo Yasuyo
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
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Honda Takeaki
Department Of Hypertension And Cardiorenal Medicine Dokkyo University School Of Medicine
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Nakano Nobuyuki
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
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Takahashi Toshiaki
Department Of Anesthesiology Tokyo Medical University
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Matsuoka Hiroaki
Department Of Bioscience National Cardiovascular Center Research Institute
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Ishimitsu Toshihiko
Department of Cardiology and Nephrology, Dokkyo Medical University School of Medicine
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