Cardiovascular Reactivity in Hypertensive Rats

概要

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Cardiovascular (CV) reactivity to norepinephrine (NE) and angiotensin II (Ang) was determined in the spontaneously hypertensive rat (SHR), and in the rat made hypertensive by clipping the renal artery and contralateral nephrectomy, or by deoxycorticosterone and salt administration. The full dose-response curves were obtained without anesthesia after pithing, decerebration, and vagotomy. CV reactivity to Ang was increased in the SHR, but only increased slightly in hypertension by clipping. This change in CV reactivity does not explain existent high blood pressure, since Ang content of the blood in the hypertensive states is not always increased. CV reactivity to NE was essentially unchanged in the 3 types of hypertension. The results indicate that the observed high blood pressure is not due to an increased sensitivity to NE in the hypertensive rats, and that NE must be available in a larger amount at the receptor sites in the cardiovascular system to maintain the higher blood pressure.
International Heart Journal刊行会の論文