Melatonin Secretion in Normal Pressure Hydrocephalus After Cerebral Aneurysm Rupture : Investigation Before and After Ventriculoperitoneal Shunt
スポンサーリンク
概要
- 論文の詳細を見る
Melatonin (MLT) secretion was examined in six normal pressure hydrocephalus (NPH) patients before and after ventriculoperitoneal (VP) shunt surgery. Ten healthy subjects were used as controls. Venous blood samples were taken daily at 2 p.m., 8 p.m., 2 a.m., and 8 a.m. Radioimmunoassay of MLT used a new specific antiserum and separation method achieving low cross-reactivity and high-efficiency MLT separation. Plasma levels in the control group at 2 p.m. and 2 a.m. were significantly different, showing diurnal rhythm (DR). The patients' MLT levels before VP shunt were significantly lower than control levels and the DR was absent. Postoperatively, the values were significantly different from preoperative values only at 2 a.m., but the DR reappeared. Thus, in NPH, VP shunt surgery improved the melatonin DR, probably through normalization of the dilated third ventricle.
- 日本脳神経外科学会の論文
- 1991-08-15
著者
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MORI Shigeo
Department of Pathology, Institute of Medical Science, University of Tokyo
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MASUZAWA Toshio
Department of Surgical Neurology Jichi Medical School
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Masuzawa Toshio
Department Of Neurosurgery Jichi Medical School
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KAWASHIMA Koichiro
Department of Mechanical Engineering, Nagoya Institute of Technology
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Yamada Naoshi
Department of Applied Physics, School of Engineering, Nagoya University
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FUJIMOTO Kazuko
Department of Pharmacology, Kyoritsu College of Pharmacy
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IWASA Hideaki
Department of Surgical Neurology, Jichi Medical School, Omiya Medical Center
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KUROKAWA Norikazu
Department of Surgical Neurology, Jichi Medical School
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Iwasa Hideaki
Department Of Surgical Neurology Jichi Medical School Omiya Medical Center
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Kurokawa Norikazu
Department Of Surgical Neurology Jichi Medical School
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Mori Shigeo
Department Of Gastroenterology Shizuoka General Hospital
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Mori Shigeo
Department Of Surgical Neurology Jichi Medical School Omiya Medical Center
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Kawashima Koichiro
Department Of General Education Nagoya University
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Yamada Naoshi
Department Of Surgical Neurology Jichi Medical School Omiya Medical Center
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Yamada Naoshi
Department Of Applied Physics School Of Engineering Nagoya University
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Fujimoto Kazuko
Department Of Phamacology Kyoritsu College Of Pharmacy
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Mori Shigeo
Department Of Equilibrium Adaptation Research Division Of Higher Nervous Control Research Institute
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Kawashima Koichiro
Department Of Phamacology Kyoritsu College Of Pharmacy
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KAWASHIMA Koichiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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