Inhibitory Effects of Verapamil and Nitroglycerin on Contraction and Cytosolic Ca^<2+> Levels in Cerebrovascular Smooth Muscle During Chronic Cerebral Vasospasm
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概要
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The mechanisms of the inhibitory effects of verapamil and nitroglycerin on vasospasm were investigated by measuring cytosolic Ca^<2+> level ([Ca^<2+>]_i) and muscle tension in 28 normal specimens and 28 spastic vascular specimens of smooth muscle. Experimental vasospasm was produced by the two-hemorrhage method in the canine basilar artery. [Ca^<2+>]_i and tension were recorded simultaneously with a fiuorimeter using fura-2. High K^+ concentration (72.4 mM) and U-46619 (thromboxane A_2 analogue, 10^<-8>M) were used as stimulants, and the inhibitory effects of verapamil or nitroglycerin on muscle contraction and increased [Ca^<2+>]_i were examined. Verapamil inhibited [Ca^<2+>]_i and contraction in high K^+ concentration-stimulated arteries. Verapamil inhibited [Ca^<2+>]_i more strongly than contraction in U-46619-stimulated arteries. There were no significant differences in the effects of verapamil in the control and vasospasm groups. Nitroglycerin inhibited contraction with little effect on [Ca^<2+>]_i in high K^+ concentration-stimulated arteries in both the control and vasospasm groups. Nitroglycerin inhibited contraction with little effect on [Ca^<2+>]_i in U-46619-stimulated arteries and the inhibitory effect was weaker in the vasospasm group than in the control group. The inhibitory effects of verapamil on muscle tension and [Ca^<2+>]_i in vasospastic vessels were as strong as those in normal vessels. In contrast, the inhibitory effects of nitroglycerin were reduced in vasospastic vessels. Increased Ca^<2+> sensitivity in vasospastic vessels may have reduced the inhibitory effects of nitroglycerin.
- 日本脳神経外科学会の論文
- 2001-05-15
著者
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YAMADA Takeshi
Department of Cardiology, Kouseikai Takeda Hospital
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SAITO Mitsuru
Department of Health Science, Aichi-Gakuin University
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MASUZAWA Toshio
Department of Surgical Neurology Jichi Medical School
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Masuzawa Toshio
Department Of Neurosurgery Jichi Medical School
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Tanaka Yuichi
Department Of Electronics And Electrical Engineering Keio University
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Saito Mitsuru
Department Of Electrical Engineering National Defense Academy
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Tanaka Yuichi
Department Of Surgical Neurology Jichi Medical School
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Saito Mitsuru
Department Of Surgical Neurology Jichi Medical School
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Yamada Takeshi
Department Of Surgical Neurology Jichi Medical School
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Yamada Takeshi
Department Of Anesthesiology Iida Municipal Hospital
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TANAKA Yuichi
Department of Chemistry, Faculty of Science, Science University of Tokyo, Kagurazaka
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