Tacrine Increases Stimulation-Evoked Acetylcholine Release from Rat Hippocampal Slices.
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概要
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We examined the effects of tacrine (9-amino-1, 2, 3, 4-tetrahydroacridine) on endogenous acetylcholine (ACh) release from rat hippocampal slices. Tacrine (more than 1 μM) increased the measurable amount of basal ACh release. On the other hand, in the presence of physostigmine (50 μM; under this condition, cholinesterase activity was inhibited), tacrine did not enhance the basal ACh release. Tacrine at more than 100 μM increased the submaximal electrical stimulation-evoked release of ACh in both the absence and presence of physostigmine (50 μM). This effect of tacrine was abolished by a combination of atropine (100 nM) and physostigmine. These results indicate that a high-dose of tacrine increases cholinergic neurotransmission not only by inhibition of cholinesterase but also by increasing ACh release through an atropine-like effect, perhaps by blockade of part of the process of muscarinic autoinhibition.
- 公益社団法人 日本薬理学会の論文
著者
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FUJIMOTO Kazuko
Department of Pharmacology, Kyoritsu College of Pharmacy
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Fujimoto Kazuko
Department Of Phamacology Kyoritsu College Of Pharmacy
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Suzuki Takeshi
Department Of Allergy And Rheumatology Graduate School Of Medicine University Of Tokyo
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KAWASHIMA Koichiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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SUZUKI Takeshi
Department of Pharmacology, Kyoritsu College of Pharmacy
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Nonaka Hikaru
Department of Pharmacology, Kyoritsu College of Pharmacy
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