Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells
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概要
- 論文の詳細を見る
To study the anti-tumor activity of sea cucumber extracts, human colon adenocarcinoma Caco-2 cells were exposed to hot water extract of sea cucumber. Morphological changes with apoptotic bodies were observed in the cells treated with the extract. We demonstrated the induction of apoptosis using phosphatidylserine translocation (APOPercentage Assay kit), terminal deoxynucleotide transferase-mediated dUTP-biotin nick-end labeling (TUNEL), and DNA fragmentation observed as DNA ladder. These results show that apoptosis was induced by a high molecular weight fraction in a dose dependent manner. These data suggest that water soluble and high molecular weight compounds from sea cucumber might exhibit anti-tumor activity by triggering apoptosis. The apoptosis-inducing activity may contribute to cancer chemopreventive effects of sea cucumber.
- 社団法人 日本食品科学工学会の論文
- 2006-11-01
著者
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Suzuki Takeshi
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Yoshie Stark
Department Of Food Science And Technology Faculty Of Marine Science Tokyo University Of Marine Scien
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OGUSHI Mariko
Department of Food Science and Technology, Faculty of Marine Science, Tokyo University of Marine Sci
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Yoshie Stark
Department Of Food Science And Technology Faculty Of Marine Science Tokyo University Of Marine Scien
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Ogushi Mariko
Department Of Food Science And Technology Faculty Of Marine Science Tokyo University Of Marine Scien
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Suzuki Takeshi
Department Of Allergy And Rheumatology Graduate School Of Medicine University Of Tokyo
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Yoshie Stark
Department Of Food Life Science Faculty Of Life Science Toyo University
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SUZUKI Takeshi
Department of Food Science and Technology, Faculty of Marine Science, Tokyo University of Marine Science and Technology
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