Cytostatic Activity of Hot Water Extracts from the Sea Cucumber in Caco-2
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概要
- 論文の詳細を見る
Sea cucumber is a traditional food item in Asia and has been reported to exhibit antifungal, antitumor, and antioxidant bioactivity as well as other properties. In this study, sea cucumbers were treated with hot water at 98°C for 60min to prepare extracts that were then used to assess their effect on the proliferation and H2O2 susceptibility of human colon adenocarcinoma Caco-2 cells. The growth of Caco-2 cells was significantly inhibited by sea cucumber extracts in a dose dependent manner. Cell proliferation was inhibited by high molecular weight sea cucumber extract at a concentration of 0.108mg/mL. No growth was observed at 1.04mg/mL of the hot water extract after 96h incubation. Cell damage by sea cucumber extract was evident above 1mg/mL. H2O2 showed concentration dependent cytotoxity to Caco-2 cells. In addition, coadministration of sea cucumber extracts intensified the H2O2 cytotoxity.
- 社団法人 日本食品科学工学会の論文
- 2005-05-01
著者
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Suzuki Takeshi
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Yoshie Stark
Department Of Food Science And Technology Faculty Of Marine Science Tokyo University Of Marine Scien
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OGUSHI Mariko
Department of Food Science and Technology, Faculty of Marine Science, Tokyo University of Marine Sci
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Yoshie Stark
Department Of Food Science And Technology Faculty Of Marine Science Tokyo University Of Marine Scien
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Ogushi Mariko
Department Of Food Science And Technology Faculty Of Marine Science Tokyo University Of Marine Scien
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Suzuki Takeshi
Department Of Allergy And Rheumatology Graduate School Of Medicine University Of Tokyo
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Yoshie Stark
Department Of Food Life Science Faculty Of Life Science Toyo University
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SUZUKI Takeshi
Department of Food Science and Technology, Faculty of Marine Science, Tokyo University of Marine Science and Technology
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