Amrubicin Monotherapy for Elderly Patients with Previously Treated Lung Cancer
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概要
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Objective The novel anthracycline agent amrubicin, has been approved in Japan to treat small and non-small cell lung cancers (SCLC and NSCLC). The present study evaluates the toxicity and effect of amrubicin especially in elderly patients with previously treated lung cancer. Patients and Methods This retrospective study analyzed data from 51 patients (<70 years of age, n=29; ≥70 years of age, n=22) with lung cancer (NSCLC, n=21; SCLC, n=30) who were treated with amrubicin at our hospital, between July 2003 and October 2009. All patients had recurrent or refractory lung cancer after one or more chemotherapy regimens. We compared the outcomes of patients younger and older than 70 years of age. Amrubicin (30-40 mg/m2/day) was infused depending on patient performance status and laboratory data over a period of 5 minutes on days 1-3, with courses repeated at intervals of at least 3 weeks. The dose was modified according to myelosuppression. Results The mean number of treatment cycles, mean dose and mean interval of amrubicin administration did not significantly differ between patients aged <70 and ≥70 years. The rate of hematological toxicities (≥ Grade 3) also did not significantly differ between the two age groups (leukopenia, 48.3% and 59.1% for age <70 and ≥70 years, p=0.573; neutropenia, 65.5% vs. 77.3%, p=0.536; anemia, 20.7% vs. 22.7%, p=1.000; thrombocytopenia, 13.8% vs. 31.8%, p=0.173). The incidence of grade 2-4 non-hematological toxicities also did not significantly differ between the groups. The response rate of SCLC and disease control rate of NSCLC were similar in the younger and older groups. Conclusion Amrubicin monotherapy might be equally tolerated by elderly and younger patients. Further studies are needed to investigate the benefit of amrubicin monotherapy among elderly patients with previously treated lung cancer.
著者
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Iwashima Yasuhito
Department Of Medical Oncology And Immunology Nagoya City University Graduate School Of Medical Scie
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Ueda Ryuzo
Department Of Applied Physics Waseda University
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Oguri Tetsuya
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine Hiroshi
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Maeno Ken
Department Of Medical Oncology And Immunology Nagoya City University Graduate School Of Medical Scie
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Miyazaki Mikinori
Department Of Medical Oncology And Immunology Nagoya City University Graduate School Of Medical Scie
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Nakao Makoto
Department Of Electrical Engineering Shinshu University
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Suzuki Takeshi
Department Of Allergy And Rheumatology Graduate School Of Medicine University Of Tokyo
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Sato Shigeki
Department Of Electrical Engineering Faculty Of Science And Technology Tokyo University Of Science
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TOMITA Yuki
Department of Dermatology and Clinical Research Institute, National Sapporo Hospital
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Nakao Makoto
Department of Medical Oncology and Immunology, Nagoya City University School of Medical Sciences
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Iwashima Yasuhito
Department of Medical Oncology and Immunology, Nagoya City University School of Medical Sciences
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Maeno Ken
Department of Medical Oncology and Immunology, Nagoya City University School of Medical Sciences
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Miyazaki Mikinori
Department of Medical Oncology and Immunology, Nagoya City University School of Medical Sciences
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Kunii Eiji
Department of Medical Oncology and Immunology, Nagoya City University School of Medical Sciences
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Ueda Ryuzo
Department of Medical Oncology and Immunology, Nagoya City University School of Medical Sciences
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Kunii Eiji
Department of Internal Medicine, Gifu Prefectural Tajimi Hospital
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Sato Shigeki
Department of Medical Oncology and Immunology, Nagoya City University School of Medical Sciences
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Sato Shigeki
Department of Applied Chemistry, Yamanashi University
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