Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases : Water Channel Aquaporin-2 of Kidney Collecting Duct Cells
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概要
- 論文の詳細を見る
Aquaporin-2 (AQP2) is one of the membrane water channel proteins expressed in principal cells of the kidney collecting ducts. In the basal state, AQP2 resides in the storage vesicles localized in the subapical cytoplasm. Upon stimulation with vasopressin, AQP2 is translocated to the apical plasma membrane by the exocytic fusion of the storage vesicles with the apical membrane. This translocation enables the transepithelial reabsorption of water from the lumen to the interstitium via AQP2 at the apical membrane and AQP3/AQP4 at the basolateral membrane. AQP2-storage vesicles are distinct from the endoplasmic reticulum, Golgi apparatus, trans-Golgi network, and lysosomes. The early endosomal marker EEA1 is colocalized with some of AQP2 vesicles. Further analyses in Madin-Darby canine kidney (MDCK) cells transfected with AQP2 revealed that subapical Rab11-positive/EEA1-negative smaller vesicles constitute part of the AQP2 storage vesicles for the translocation to the apical membrane. Termination of stimulation results in the retrieval of AQP2 to the larger EEA1-positive early endosomal compartment. AQP2 is then transferred to the subapical storage compartment in a PI3-kinase-dependent manner. GLUT4 is an isoform of glucose transporters whose localization is also regulated by vesicular trafficking induced by insulin stimulation. Comparison of the intracellular localization of AQP2 with GLUT4 suggests distinct regulation of AQP2 trafficking.
- 社団法人 日本薬理学会の論文
- 2004-11-20
著者
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Aoki Toshihiro
宮崎大学 医学部内科学第1
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Tajika Y
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Suzuki Takeshi
Department of Internal Medicine, Nippon Medical School
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Tajika Yuki
Department of Anatomy, Gunma University Graduate School of Medicine
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Tajika Yuki
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Suzuki T
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Matsuzaki Toshiyuki
Department of Anatomy and Cell Biology, Gunma University School of Medicine
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Aoki Takeo
Department of Anatomy and Cell Biology, Gunma University School of Medicine
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Hagiwara Haruo
Department of Anatomy and Cell Biology, Gunma University School of Medicine
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Takata Kuniaki
Department of Anatomy and Cell Biology, Gunma University School of Medicine
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Aoki T
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Aoki Toshihiro
First Department Of Internal Medicine Miyazaki Medical College
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Aoki Takeo
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Ablimit Abdushukur
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine
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ABDUXUKUR Ablimit
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine
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Ablimit Abdushukur
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Takata Kuniaki
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Takata K
Kyorin Univ. School Of Medicine Tokyo
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Takata K
Laboratory Of Molecular And Cellular Morphology Department Of Cell Biology Institute For Molecular A
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Hagiwara Haruo
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Suzuki Takeshi
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Matsuzaki Toshiyuki
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Takata Kuniaki
Laboratory Of Molecular And Cellular Morphology Institute For Molecular And Cellular Regulation Gunm
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Aoki Toshihiro
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Suzuki Takeshi
Department Of Allergy And Rheumatology Graduate School Of Medicine University Of Tokyo
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