Effects of Nitrites on Arterial Collateral Vessels of Dogs

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In dogs weighing about 10Kg. anesthetized with pentobarbital, resistances of the collateral flow channels of the common carotid and femoral arteries were studied during occlusion of these arteries. When the common carotid artery was occluded, collateral resistance gradually decreased in about 30sec., from initial collateral resistance (ICR) of 0.842±0.165mm.Hg/ml./min. (mean with SE from 6 dogs) to steady state collateral resistance (SCR) of 0.519±0.111 (-39.4±3.6%, significant at P<0.001). Intravenous injection of a long-active nitrite, N-ethoxy-carbonyl-3-morpholinosydnonimine (SIN-10), at a dose of 1mg./Kg., diminished ICR (-37.5±5.3%, n=6, P<0.001, 15min. after administration) but not SCR, thus ICR approached SCR. This effect was marked 5-60min.after the intravenous injection. ICR of the femoral artery was also decreased by SIN-10 (-48.7±5.8%, n=6, significant at P<0.001).Nitroglycerin had a similar effect of dilating the collateral vessels for both arteries, though its effect was more evanescent in the time course and almost disappeared 5min. after injection. It is concluded that nitrites dilate almost the same collateral vasculature which would gradually open during arterial occlusion without nitrites.
International Heart Journal刊行会の論文