Effects of Alpha and Beta Blockers on Hemodynamics of SHR
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概要
- 論文の詳細を見る
Relationships of doses of α- and β-adrenergic receptor blockers to arterial pressure, cardiac output, total peripheral resistance, and heart rate were observed in SHR (spontaneously hypertensive rat) and NCR (normotensive control rat) under pentobarbital anesthesia and positive pressure respiration. The decreases in arterial pressure and total peripheral resistance by phenoxybenzamine were greater in SHR than in NCR. By increasing dose of this drug, the differences in these parameters between SHR and NCR were gradually diminished and finally disappeared. Propranolol induced a similar equalization of heart rate between SHR and NCR. These findings are consistent with that the hypertensive state in SHR is maintained by an elevation of the sympathetic tone. Sympathetic vasoconstrictors seem to play a major role over cardiac sympathetics in the hypertension of SHR, since propranolol alone could not markedly diminish the arterial pressure in SHR.
- International Heart Journal刊行会の論文
著者
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NUMAO Yoshinobu
Department of Physiology, Faculty of Medicine, University of Tokyo
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IRIUCHIJIMA Juro
Department of Physiology, Faculty of Medicine, University of Tokyo
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IRIUCHIJIMA Juro
Department of Physiology and Institute of Medical Electronics, Faculty of Medicine, University of Tokyo
関連論文
- Hemodynamics of Experimentally Hypertensive Rats in Conscious and Anesthetized States
- Correlative Changes in Total Vascular Capacity and Resistance in Carotid Sinus Reflex
- Effect of Increasing Age on Hemodynamics of Spontaneously Hypertensive Rats
- Hemodynarnics of Spontaneously Hypertensive Rats in Conscious State
- Effects of Alpha and Beta Blockers on Hemodynamics of SHR
- Sympathetic Nervous Activity in Renal and DOC Hypertensive Rats
- Distribution of Cardiac Output in Conscious Animals : SIMPOSIUM ON EXPERIMENTAL AND CLINICAL TOPICS IN THE REGULATION OF THE CIRCULATION
- Measurement of Aortic Compliance in Vivo
- Sympathetic Discharge Rate in Spontaneously Hypertensive Rats
- Cardiac Output and Total Peripheral Resistance in Spontaneously Hypertensive Rats
- Arterial Pressure in Spontaneously Hypertensive Rats After High Spinal Cord Section
- Cardiac Output in Conscious SHR