EFFECTS OF STARVATION ON MICROSOMAL CYTOCHROME P-450 AND LAURATE-ω-HYDROXYLATION OF RAT KIDNEY AND LIVER
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概要
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Cytochrome P-450 (P-450) content and laurate-ω-oxidation activity in rat kidney and liver microsomes were investigated following starvation. Multiple forms of P-450 were analyzed by one dimensional separation using peroxidase stained SDS-continuous gradient polyacrylamide gel electrophoresis. Gels of the hepatic microsomes treated with phenobarbital showed three P-450 bands, and the renal microsomes showed one sharp band, which was induced remarkably by starvation and coincided with the middle molecular form of P-450 from the hepatic microsomes. Since laurate-ω-oxidation activity was induced specifically by starvation but not by drug treatment, in both the kidney and the liver microsomes, the middle molecular form of P-450 might catalyze laurate-ω-oxidation. It seemed, therefore, that a special P-450 subunit catalyzing laurate-ω-oxidation has a greater function in the renal rather than hepatic microsomes because the specific laurate-ω-oxidation activity per starvation induced P-450 content was relatively similar in both the kidney and the liver.
- 社団法人 日本薬理学会の論文
著者
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HASUMURA Satoshi
Department of Internal Medicine, Jikei University School of Medicine
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Kakuno Katsuhiko
Department Of Pharmacology School Of Pharmacy Hoshi University
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SAKAI Fuminori
Department of Pharmacology, Faculty of Medicine, University of Tokyo
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Sakai Fuminori
Department Of Pharmacology Faculty Of Medicine University Of Tokyo
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ENDOW Hitoshi
Department of Pharmacology, Faculty of Medicine, University of Tokyo
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HOJO Kazuo
Department of Medicine, Nihon University School of Medicine
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HASUMURA Satoshi
Department of Medicine, Tokyo Jikei University School of Medicine
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