Prolonged Inhibition of Vascular Contraction and Calcium Influx by the Novel 1,4-Dihydropyridine Calcium Antagonist Cinaldipine (FRC-8653).
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概要
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We examined the effects of FRC-8653, a novel dihydropyridine calcium antagonist, on the contraction of an arterial preparation and the calcium influx into vascular smooth muscle cells to clarify the long-lasting hypotensive activity of this drug. Inhibition by FRC-8653 persisted for more than 7 hr after its removal, whereas nifedipine and nicardipine exhibited shorter durations of suppressive activity. These results suggest that prolonged inhibition of calcium influx through L-channels contributes to the long-lasting vasodilative and antihypertensive activity of FRC-8653.
- 公益社団法人 日本薬理学会の論文
著者
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Dohmoto Hideki
Life Science Laboratories Central Research Laboratories Ajinomoto Co. Inc.:pharmaceuticals Research
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YOSHIMOTO Ryota
Life Science Laboratories, Central Research Laboratories, Ajinomoto Co., Inc.
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GOTO Atsuo
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Yamada Kaoru
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Dohmoto Hideki
Life Science Laboratories, Central Research Laboratories, Ajinomoto Co., Inc.
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