Effects of chronic administration of captopril on blood pressure and the renin-angiotensin-aldosterone system in normotensive rats.

スポンサーリンク

概要

• 論文の詳細を見る

• The chronic effects of oral administration of an angiotensin converting enzyme inhibitor (captopril, 63-80mg/Kg/day) on blood pressure and the renin-angiotensin-aldosterone system were-studied in normotensive male Wistar rats. Blood pressure (BP), plasma renin activity (PRA), plasma renin concentration (PRC), plasma renin substrate concentration (PRS), plasma aldosterone concentration (PAC) and renal renin content (RRC) were measured after 2, 9, 19, 29 and 58 days of captopril administration. BP was determined in awake rats and blood samples were obtained by decapitation. In addition, BP responses to bolus injections of angiotensin I (AI, 80ng/Kg), angiotensin II (AII, 80ng/Kg) and bradykinin (BK, 10μg/Kg) were examined in conscious rats which had received captopril for 20 days. The BP of the rats which had been given captopril for 9 days or longer was significantly lower than that of the control rats. PRA and PRC were markedly increased, and both PRS and PAC were decreased in the captopriltreated rats. RRC, which was reduced after 2 days of captopril administration, was substantially increased thereafter. Although the pressor responses to AII were similar in the captopril treated and the control rats, the responses to AI were reduced to 50% of those to AII in the former. The depressor responses to BK in the captopril-treated rats were 2.3 times as large as those in the control rats. Our results show that long-term use of captopril lowers BP in normotensive rats on a normal sodium intake. They also suggest that the rises in PRA, PRC and RRC in the captopril-treated rats may be related to the effects of both the BP reduction and interruption of the negative feedback mechanism of All on renin release and synthesis, and that the decline in PRS is due to its increased consumption and probably also to the decreased rate of hepatic substrate synthesis induced by the fall in plasma AII.

• International Heart Journal刊行会の論文

著者

• Takeda Tadanao

  First Department Of Internal Medecine Osaka City University Medical School

• Goto Atsuo

  Second Department of Internal Medicine, University of Tokyo

• HIRATA Yasunobu

  Second Department of Internal Medicine, Faculty of Medicine

• Murao Satoru

  Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Ishii Masao

  Second Department Of Internaal Medicine Yokohama City University

• KIMURA Kenjiro

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• YAMAKADO Minoru

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• MURAO Satoru

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• HIRATA Yasunobu

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• GOTO Atsuo

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

関連論文

• -2-ELECTROCARDIOGRAPHIC FINDINGS OF NOCTURNAL ANGINA : COMPARISON BETWEEN ANGINA WITH ST SEGMENT ELEVATION AND ANGINA WITH ST SEGMENT DEPRESSION : Ischemic Heart Disease : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• EXCITABILITY OF VENTRICULAR MYOCARDIUM AND THE EFFECT OF ANTIARRYTHMIC DRUGS : IVth Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• CERTAIN PROPERTIES OF THE MYOCARDIUM AS AN ELECTRICAL GENERATOR : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -P613- Calcium channel antagonist prevents cardiac hypertrophy induced by isoproterenol(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -0907- The effect of TCV-116, angiotensin II type I receotor antagonist, ont the cardiac phenotype and extracelullar matrix in left ventricular remodeling after myocardial infarction.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCU
• -0669- Isosorbide Dinitrate Suppresses Protooncogene Expression on Ischemia-Reperfusion Injury(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• The role of angiotensin II type l receptor to the left ventricular remodeling after myocardial infarction
• Protooncogene expression on ischemia-reperfusion injury
• Brain Natriuretic Peptide in Hypertension
• Vascular Dopamine-I Receptors
• ENHANCEMENT OF VOLTAGE SENSITIVE CALCIUM CHANNEL ACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
• ROLE OF NITRIC OXIDE IN THE VASODILATORY RESPONSES TO ACETYLCHOLINE AND BRADYKININ IN PERFUSED HEARTS
• TWO-DIMENSIONAL AND DOPPLER ECHOCARDIOGRAPHIC FINDINGS IN A CASE OF SUBAORTIC "FIBROUS SAC"
• SIGNIFICANCE OF Q WAVE DISAPPEARANCE IN THE CHRONIC PHASE FOLLOWING TRANSMURAL ACUTE MYOCARDIAL INFARCTION
• -0847-CLINICAL SINGNIFICANCE OF PLATELET-DERIVED GROWTH FACTOR (PDGF) IN THE RESTENOSIS AFTER PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY (PTCA) : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• THE COMPLEMENT SYSTEM IN THE ACUTE PHASE OF MYOCARDIAL INFARCTION
• ASSESSMENT OF MECHANISMS OF CALCIUM PARADOX USING 31P-MRS : Pathophysiology : 53 Annual Scientific Meeting, Japanese Circulation Society
• -140-THE ENDOMYOCARDIAL BIOPSY FINDINGS AND CLINICAL FEATURES OF HEAVY DRINKERS WITH HEART FAILURE IN COMPARISON WITH THOSE OF PATIENTS OF DILATED CARDIOMYOPATHY : Cardiomyopathy : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING
• Physiological Significance of Atrial Natriuretic Peptides in Essential Hypertension : SYMPOSIUM ON ATRIAL NATRIURETIC POLYPEPTIDE (ANP): Basic and Clinical Research : 51th Annual Scientific Session of the Japanese Circulation Society
• -293-EFFECTS OF ANTI-ANGINAL AGENTS ON CYCLICAL REDUCTION OF CORONARY FLOW ASSOCIATED WITH ST ELEVATION : Coronary Circulation : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• CYCLICAL REDUCTION IN BLOOD FLOW OF PARTIALLY CONSTRICTED CORONARY ARTERY IN DOGS II. AN ARTERIOGRAPHIC STUDY
• EFFECTS OF ASPIRIN, INDOMETHACIN AND THE OTHER AGENTS WHICH INHIBIT PROSTAGRANDIN SYNTHESIS ON CYCLICAL REDUCTION IN BLOOD FLOW OF PARTIALLY CONSTRICTED CORONARY ARTERY : IIIrd Auditorium
• EFFECT OF ANTI-ANGINAL AGENTS AND CA^ ON MINUTE RHYTHM OF CONSTICTED CORONARY ARTERY : Vth Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• PHASIC CONTRACTION OF CORONARY ARTERY SMOOTH MUSCLE
• EFFECT OF EXTRASTIMULATION ON CANINE ECTOPIC ATRIAL AND VENTRICULAR TACHYCARDIA INDUCED BY ACONITINE : Electrophysiology : 46th Annual Scientific Meeting, Japanese Circulation Society
• -0605-RELEASE OF IMMUNOREACTIVE ENDOTHELIN FROM PORCINE AORTIC STRIPS
• -P113-EFFECT OF ENDOTHELIN ON ADENYLATE CYLASE : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• ABSOLUTE MAGNITUDE OF THE ELECTROMOTIVE FORCE OF MYOCARDIUM AND THE EFFECT OF THE SURROUNDING MEDIUM : Ist Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• EFFECT OF ARRHYTHMIA ON LEFT VENTRICULAR FUNCTION : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Angiotensin II Type-1 Receptor Antagonist as Well as Angiotensin Converying Enzyme Inhibitor Attenuates the Development of Heart Failure in Aortocaval Fistula Rats
• Myocardial Infarct Size by Serum Troponin T and Myosin Light Chain 1 Concentration
• ESTIMATION OF INFARCT SIZE USING SERUM TROPONIN T CONCENTRATION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
• EVALUATION OF MYOCARDIAL ISCHEMIA WITH INOTROPIC AGENTS BY PHOSPHORUS-31 NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
• TIME COURSE OF THE RECOVERY OF ADENOSINE TRIPHOSPHATE CONTENT WITH DENOSINE IN POST-ISCHEMIC HEARTS : A ^P Magnetic Resonance Spectroscopy Study
• THE DELETERIOUS EFFECTS OF EXOGENOUS ANGIOTENSION I AND ANGIOTENSIN II ON MYOCARDIAL ISCHEMIA-REPERFUSION INJURY
• CLINICAL SIGNIFICANCE OF REVERSE REDISTRIBUTION ON THALLIUM-201 SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
• -0552-CIRCULATING IMMUNOREACTIVE ENDOTHELIN IN ESSENTIAL HYPERTENSION
• -506- THE EFFECT OF GLUCOCORTICOID ON BETA, DOPAMINE AND PROSTAGLANDIN E_1 RECEPTORS ON HUMAN ASTROCYTOMA CLONE
• Restoration of Endothelial Cell Function by Chronic Cicletanine Treatment in Dahl Salt-Sensitive Rats with Salt-Induced Hypertension
• Effects of Intracerebroventricular Infusion of Fab Fragments of Digoxin Antibody(Digibind) on Development of Reduced Renal Mass-Saline Hypertension in Rats
• EFFECTS OF INTRACEREBROVENTRICULAR(ICV)PREINJECTION OF Fab FRAGMENT OF DIGOXIN ANTIBODY(DIGIBIND)ON THE NATRIURESIS AND INCREASE IN BLOOD PRESSURE INDUCED BY ICV INGUSION OF HYPERTONIC SALINE SOLITION IN RATS
• Sandwich Radioimmunoassay of Human Plasma Renin Using Two Monoclonal Antibodies : THE 17th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• Improved Nitric Oxide Detection Using 2,3-Diaminonaphthalene and Its Application to the Evaluation of Novel Nitric Oxide Synthase Inhibitors
• DEVELOPMENT OF A FLUORESCENT INDICATOR FOR NITRIC OXIDE BASED ON THE FLUORESCEIN CHROMOPHORE
• Development of a Fluorescent Indicator for the Bioimaging of Nitric Oxide
• EFFECTS OF RAT ATRIAL EXTRACT ON URINARY EXCRETION OF SODIUM AND PROSTAGLANDIN E_2 : Circulation Control : V : 48 Annual Scientific Meeting, Japanese Circulation Society
• Dilatation of the Aortic Valve Portion in Aortitis Syndrome : Angiographic Evaluation of 70 Patients
• A 17-year Follow-up Study of a Family with Idiopathic Hypertrophic Cardiomyopathy and WPW Syndrome
• Effects of a Prostaglandin I2 Analogue, ZK 36374, on Recurring Reduction of Coronary Blood Flow
• Effects of Thromboxane Synthetase Inhibitors on Cyclical Reduction of Coronary Blood Flow in Dogs
• Prostaglandin E2 and Epinephrine Participate in Cyclical Reduction of Coronary Blood Pressure and Flow
• Effect of 2-Nicotinamidethyl Nitrate (SG 75) on Coronary Circulation
• Effects of Anti-Anginal Agents on Cyclical Reductions of Coronary Blood Flow
• Cyclic Fluctuations in Coronary Blood Pressure and Flow Induced by Coronary Artery Constriction
• Excitation of Afferent Cardiac Sympathetic Nerve Fibers Induced by Vagal Stimulation
• Effects of α-Human Atrial Natriuretic Polypeptide (α-hANP) on the Main Regulatory Mechanisms for Blood Pressure and Body Fluid Volume in Rats : THE 14th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• Inhibition of Captopril-induced Increase in Plasma Renin Activity by Propranolol
• Exercise Test in Variant Form of Angina Pectoris : Comparison of the Results with Spontaneous Attacks
• An Experimental Model of Giant Negative T Wave Associated with QT Prolongation Produced by Combined Effect of Calcium and Isoproterenol
• Effects of Acute Changes in Left Ventricular Size on Surface Potential in Man
• "Entrainment" Phenomenon during Reciprocating Tachycardia in the Wolff-Parkinson-White Syndrome
• Mitral Regurgitation Associated with Aortitis Syndrome
• Left Ventricular Function and Power Distribution during Ejection Period in Patients with Cardiac Diseases
• Ventricular Fibrillation Initiated by Low Sodium and Potassium Solution : I. Experiment in Isolated Frog Heart
• Pacing Echocardiography : Regional Wall Motion, Left Ventricular Dimension and R Wave Amplitude in Patients with Angina Pectoris
• The Significance of T-Loop Change in Franks Lead Exercise Electrocardiography
• Two Cases of Complex A-V Interference-Dissociation
• Observations upon Some Aspects of A-V Conduction in Advanced A-V Block
• Cardiac Function under Myocardial Ischemia
• Cardiac Sarcoidosis with Twelve-year Survival
• Etiology of QT Prolongation and T Wave Changes in Chronic Alcoholism
• Prevalence of Concentric Left Ventricular Hypertrophy in "Non-cardiac" Alcoholics : An Echocardiographic Study
• Variable Prognosis in Congestive Cardiomyopathy : Role of Left Ventricular Function, Alcoholism, and Pulmonary Thrombosis
• EFFECT OF PROSTAGLANDIN I_2 ON CYCLICAL REDUCTIONS OF CORONARY BLOOD FLOW
• Nocturnal Angina Pectoris : Comparison between Angina with ST Segment Elevation and Depression Documented by Continuous Orthogonal ECG Recording
• Experimental Production of Ventricular Complex Simulating A, B, and C Types of WPW Syndrome
• The Current Status of Ischemic Heart Disease and Myocardial Infarction in Japan
• Studies with Tritiated Digoxin in Renal Failure and Diabetes Mellitus
• Spatial T Wave Changes Produced by Exercise in Health and Disease
• Nitroglycerin-Induced Suppression of Excitation of Afferent Cardiac Sympathetic Nerves During Myocardial Ischemia
• DECREASE IN BLOOD FLOW THROUGH PARTIALLY CONSTRICTED CORONARY ARTERY AND EXCITATION OF AFFERENT CARDIAC SYMPATHETIC NERVE FIBERS FOLLOWING SYMPATHETIC STIMULATION
• An Autopsied Case of Eisenmenger Syndrome Complicated by Recurrent Thromboembolic Phenomena in Postpartal Period
• An Analytical Study on Aberrant Ventricular Conduction : Part I. A General Rule
• The Effect of Angiotensin-Converting Enzyme Inhibition on Regional Blood Flow in Salt-Depleted and Salt-Loaded Normotensive Conscious Rats
• A Graphical Method for Evaluation of Narrowing of the Coronary Arteries (Coronary Profile Method)-With Special Reference to Intramural Arteriolosclerosis
• A Case of Coronary Sclerosis in Small Arteries Associated with Diffuse Myocardial Fibrosis
• Primary Cardiomyopathy : Clinical Spectrum of Adult Japanese Patients
• Peripartal Cardiomyopathy in Japan : A Critical Reappraisal of the Concept
• Sustained Decrease in Coronary Blood Flow and Excitation of Cardiac Sensory Fibers Following Sympathetic Stimulation
• Effects of chronic administration of captopril on blood pressure and the renin-angiotensin-aldosterone system in normotensive rats.
• Role of the aldosterone system in the salt-sensitivity of patients with benign essential hypertension.
• Acute hemodynamic effects of alpha human atrial natriuretic polypeptide in patients with congestive heart failure.
• Lack of venodilative activity of alpha human atrial natriuretic polypeptide in patients with congestive heart failure.
• Nephrogenous cyclic GMP production during NaCl loading and ANP infusion.
• Plasma concentration of atrial natriuretic polypeptide in patients with atrial tachycardia.
• Blood pressure, renal and endocrine responses to .ALPHA.-human atrial natriuretic polypeptide in healthy volunteers.
• An adult case of arrhythmogenic right ventricular dysplasia.
• Myocardial contractility and contraction duration are unrelated in the left ventricle with moderate pressure-overload hypertrophy.
• Effects of chronic administration of atrial natriuretic polypeptide on glomerular lesions in spontaneously hypertensive rats.
• Effect of Prolonged Beta-Adrenergic Blockade Induced by Atenolol on Left Ventricular Remodeling after Acute Myocardial Infarction in the Rat.

もっと見る 閉じる

スポンサーリンク