Plasma concentration of atrial natriuretic polypeptide in patients with atrial tachycardia.
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the mechanisms of polyuria associated with tachycardia, we measured plasma concentrations of α-human atrial natriuretic polypeptide (α-hANP) and cGMP in 6 patients with paroxysmal tachycardia. Plasma concentrations of immunoreactive α-hANP and cGMP increased by +69% (p<0.05) and +100% (p<0.05), respectively, during both paroxysmal atrial tachycardia and atrial fibrillation. To examine whether tachycardia per se raises the secretion of α-hANP, we also determined plasma concentrations of α-hANP and cGMP in 5 patients during rapid atrial pacing. The pacing-induced tachycardia also increased both of the plasma concentrations. Further, the examinations of cardiac and renal functions in patients with complete atrioventricular block during rapid pacing revealed that each of the increases in atrial pressures, urinary sodium excretion and creatinine clearance were in parallel with the change in plasma concentration of α-hANP. These results suggest that an increase in plasma concentration of α-hANP during paroxysmal tachycardia is mainly due to elevation of atrial pressure and that this increase in α-hANP contributes to tachycardia polyuria.
- International Heart Journal刊行会の論文
著者
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Toda Iku
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Murakawa Yuji
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Nozaki Akira
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Kangawa Kenji
Second Division, Department of Medicine, Kyoto University School of Medicine, Kyoto, and Department
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MIYATA ATSURO
Second Department of Biochemistry, Miyazaki Medical College
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HIRATA Yasunobu
Second Department of Internal Medicine, Faculty of Medicine
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Sugimoto Tsuneaki
Second Department Of Internal Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Univers
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Sugimoto Tokuichiro
Second Department Of Internal Medicine University Of Tokyo
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Ishii Masao
Second Department Of Internaal Medicine Yokohama City University
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MATSUOKA Hiroaki
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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SUGIMOTO Tokuichiro
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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MATSUO Hisayuki
Second Department of Biochemistry, Miyazaki Medical College
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KANGAWA Kenji
Second Department of Biochemistry, Miyazaki Medical College
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MIYATA Atsuro
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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