Blood pressure, renal and endocrine responses to .ALPHA.-human atrial natriuretic polypeptide in healthy volunteers.

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概要

• 論文の詳細を見る

• Intravenous infusion of graded doses of α-human atrial natriuretic polypeptide (α-hANP) resulted in a dose-dependent decrease in blood pressure and an increase in heart rate in 11 healthy male volunteers. However, there were no significant changes in urine output or in the urinary excretion rate of sodium. Glomerular filtration rate did not change, while renal blood flow decreased, leading to significant increases in filtration fraction and renal vascular resistance. Although plasma renin activity (PRA) and plasma concentration of norepinephrine (PNE) increased during infusion of α-hANP (both p<0.001), plasma concentrations of aldosterone (PA) and cortisol (PC) decreased (both p<0.001). Plasma concentration of arginine vasopressin (PAVP) did not change during the infusion, but greatly increased after cessation of the infusion. The hematocrit increased slightly, but significantly, during the infusion. These results show that, although α-hANP has a potent hypotensive action and inhibits the secretion of aldosterone, cortisol, and probably arginine vasopressin, it does not dilate renal vessels in normotensive persons, and likely increases vascular permeability. The lack of consistent diuretic and natriuretic responses to α-hANP may be related to the predominance of the hypotensive effect over the renal effects of the peptide in normotensive persons, or a diurnal change may have served to obscure such a response.

• International Heart Journal刊行会の論文

著者

• Matsuoka Hiroaki

  Second Department of Internal Medicine, University of Tokyo

• Ishimitsu Toshihiko

  Second Department of Internal Medicine, University of Tokyc

• HIRATA Yasunobu

  Second Department of Internal Medicine, Faculty of Medicine

• Sugimoto Tsuneaki

  Second Department Of Internal Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Univers

• Sugimoto Tokuichiro

  Second Department Of Internal Medicine University Of Tokyo

• Ishii Masao

  Second Department Of Internaal Medicine Yokohama City University

• MATSUOKA Hiroaki

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• ATARASHI Keiichiro

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• MATSUO Hisayuki

  Tokyo and the Second Department of Biochemistry, Miyazaki Medical College

• KANGAWA Kenji

  Tokyo and the Second Department of Biochemistry, Miyazaki Medical College

• ISHIMITSU Toshihiko

  Second Department of Internal Medicine, University of Tokyo

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