Reduction of Thrombogenicity with Argon Laser Angioplasty. Comparison with Balloon Angioplasty.:Comparison with Balloon Angioplasty

概要

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Direct argon or thermal laser angioplasty (LA) was evaluated for thrombogenicity using angioscopy, and compared with balloon angioplasty (BA). In each of 8 dogs, 4 segments (both proximal and distal iliac arteries) were treated by laser-thermal and/or balloon angioplasty. One segment was treated by balloon angioplasty and 3 other segments were treated with either thermal LA with 7W using a "Hot-Tip" laser probe (2.0mm), or BA and thermal LA, or a special optical probe which emits a 3W argon laser beam. Mean percent area stenosis by thrombus was 44±23 in balloon-dilated, 23±21 in thermally-treated and balloondilated, 3±3 in thermally-treated, and 1±4 in directly-lased segments at 30min. It was 62±28 in balloon dilated, 31±29 in thermally-treated and balloon-dilated, 5±6 in thermally-treated, and 1±2 in directly-lased segments at 60min. Balloon-inflated segments had the highest percent area stenosis which was significantly higher than that of either the direct laser or thermally-treated segments (p<0.0005). Histology showed thermal necrosis in laser-treated sites, and wall tears in BA sites. Thus, LA can provide a less thrombogenic arterial surface than BA.
International Heart Journal刊行会の論文