Nephrogenous cyclic GMP production during NaCl loading and ANP infusion.
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概要
- 論文の詳細を見る
To further study the mechanisms of the renal effects of ANP, we examined the effects of NaCl loading and ANP infusion on nephrogenous cGMP production. Six normotensives (NTs) and 7 essential hypertensives (HTs) were placed on 7-day low (3g/day) and then 7-day high NaCl diets (20g/day). On the last day of each period, the natriuretic and nephrogenous cGMP responses to ANP infusion at 25ng/kg/min for 40min were determined. ANP infusion markedly increased the plasma concentrations of ANP and cGMP and the urinary excretions of Na and cGMP. These changes were accompanied by a rise in nephrogenous cGMP. Increases in nephrogenous cGMP during ANP infusion were not different between HTs and NTs despite a greater natriuretic response in HTs. NaCl loading significantly increased the natriuretic response to ANP infusion in both groups. However, nephrogenous cGMP production induced by ANP infusion was not affected by changes in NaCl intake. Thus, although ANP-induced natriuresis is associated with an increase in nephrogenous cGMP, the natriuretic effect of ANP seems to be modified to a greater extent by indirect mechanisms such as renal perfusion pressure and body fluid volume status.
- International Heart Journal刊行会の論文
著者
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Ishimitsu Toshihiko
Second Department of Internal Medicine, University of Tokyc
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HIRATA Yasunobu
Second Department of Internal Medicine, Faculty of Medicine
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Sugimoto Tsuneaki
Second Department Of Internal Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Univers
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Sugimoto Tokuichiro
Second Department Of Internal Medicine University Of Tokyo
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KIMURA Kenjiro
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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MATSUOKA Hiroaki
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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FUKUI Kazushige
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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HAYAKAWA Hiroshi
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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NAMBA Shinichiro
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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ISHIMITSU Toshihiko
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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